Clinical Trials: SEARCH[Study] TILT[Study:StudyFirstPostDate] AREA[InterventionSearch] Fampridine-SR
#
NCTID/Status
Study
Last Changed
1
NCT04148781
Not yet recruiting
Not yet recruiting
October 30, 2019
2
NCT01656148
Completed
Completed
FAME - Fampyra Outcome Measures Study: a Study of Different Outcome Measures on the Effect of Fampyra
Conditions: Multiple Sclerosis
Intervention: Fampridine-SR
Conditions: Multiple Sclerosis
Intervention: Fampridine-SR
August 22, 2018
3
NCT01667497
Completed
Completed
Does Fampridine SR Improve Cognitive Fatigue in Multiple Sclerosis Patients?
Conditions: Cognitive Fatigue
Intervention: Fampridine SR, Placebo
Conditions: Cognitive Fatigue
Intervention: Fampridine SR, Placebo
September 1, 2015
4
NCT00649792
Completed
Completed
Open-Label Extension Study to Evaluate the Safety, Tolerability and Activity of Oral Fampridine-SR in Patients With Multiple Sclerosis Who Participated in the MS-F204 Trial
Conditions: Multiple Sclerosis
Intervention: Fampridine-SR
Conditions: Multiple Sclerosis
Intervention: Fampridine-SR
February 24, 2012
5
NCT00648908
Completed
Completed
Open-Label Extension Study to Evaluate the Safety, Tolerability and Activity of Oral Fampridine-SR Tablets in Multiple Sclerosis Patients Who Participated in the MS-F203 Trial
Conditions: Multiple Sclerosis
Intervention: Fampridine-SR
Conditions: Multiple Sclerosis
Intervention: Fampridine-SR
February 24, 2012
6
NCT01235221
Completed
Completed
Open Label Extension Study to Evaluate the Safety and Tolerability of Oral Fampridine-Sustained Release (SR) in Canadian Participants With Multiple Sclerosis Who Participated in Acorda Extension Trials.
Conditions: Multiple Sclerosis
Intervention: BIIB041 (Fampridine-SR)
Conditions: Multiple Sclerosis
Intervention: BIIB041 (Fampridine-SR)
July 3, 2014
7
NCT00483652
Completed
Completed
Study of Fampridine-SR Tablets in Multiple Sclerosis Patients
Conditions: Multiple Sclerosis
Intervention: Fampridine-SR, Placebo
Conditions: Multiple Sclerosis
Intervention: Fampridine-SR, Placebo
January 4, 2016
8
NCT00127530
Completed
Completed
Study of Oral Fampridine-SR in Multiple Sclerosis
Conditions: Multiple Sclerosis
Intervention: Fampridine-SR, Placebo
Conditions: Multiple Sclerosis
Intervention: Fampridine-SR, Placebo
August 13, 2018
9
NCT00654927
Completed
Completed
Open-Label Extension Study to Evaluate the Safety, Tolerability and Activity of Oral Fampridine-SR in Patients With Multiple Sclerosis
Conditions: Multiple Sclerosis
Intervention: Fampridine-SR B.i.d. (Twice Daily)
Conditions: Multiple Sclerosis
Intervention: Fampridine-SR B.i.d. (Twice Daily)
March 1, 2012
10
NCT03899584
Not yet recruiting
Not yet recruiting
High Doses of 4-aminopyridine in Clinically Complete Chronic Spinal Cord Injury Patients.
Conditions: Spinal Cord Injuries; Chronic
Intervention: 4-Aminopyridine, Placebo Oral Capsule
Conditions: Spinal Cord Injuries; Chronic
Intervention: 4-Aminopyridine, Placebo Oral Capsule
May 29, 2019
11
NCT02422940
Terminated
Terminated
Study to Evaluate the Long-Term Safety, Tolerability and Efficacy of Dalfampridine.
Conditions: Post-ischemic Stroke
Intervention: Dalfampridine-ER 7.5 Mg, Dalfampridine-ER 10 Mg
Conditions: Post-ischemic Stroke
Intervention: Dalfampridine-ER 7.5 Mg, Dalfampridine-ER 10 Mg
January 17, 2019
12
NCT01535664
Completed
Completed
An Open Label, Proof of Concept Study to Evaluate the Effects of Dalfampridine Withdrawal on Gait and Balance Parameters in Subjects With Multiple Sclerosis (MS)
Conditions: Multiple Sclerosis
Intervention: Withdrawal Of Dalfampridine-ER 10mg
Conditions: Multiple Sclerosis
Intervention: Withdrawal Of Dalfampridine-ER 10mg
August 8, 2013
13
NCT01683838
Completed
Completed
Safety and Efficacy of Oral Fampridine-Sustained Release (SR) for the Treatment of Spasticity Resulting From Spinal Cord Injury
Conditions: Spinal Cord Injury; Muscle Spasticity
Intervention: Fampridine-SR, Placebo
Conditions: Spinal Cord Injury; Muscle Spasticity
Intervention: Fampridine-SR, Placebo
July 27, 2017
14
NCT01337986
Completed
Completed
Ampyra for Optic Neuritis in MS
Conditions: Multiple Sclerosis; Optic Neuritis
Intervention: Dalfampridine/Placebo, Placebo/Dalfampridine
Conditions: Multiple Sclerosis; Optic Neuritis
Intervention: Dalfampridine/Placebo, Placebo/Dalfampridine
February 14, 2014
15
NCT00041717
Completed
Completed
Safety and Efficacy of Oral Fampridine-SR for the Treatment of Spasticity Resulting From Spinal Cord Injury
Conditions: Spinal Cord Injury; Muscle Spasticity
Intervention: Fampridine-SR, Placebo
Conditions: Spinal Cord Injury; Muscle Spasticity
Intervention: Fampridine-SR, Placebo
April 25, 2013
16
NCT01621113
Completed
Completed
Combination Therapy With Dalfampridine and Locomotor Training for Chronic, Motor Incomplete Spinal Cord Injury
Conditions: Spinal Cord Injury
Intervention: Dalfampridine, Placebo
Conditions: Spinal Cord Injury
Intervention: Dalfampridine, Placebo
November 29, 2017
17
NCT02280096
Completed
Completed
Efficacy and Safety of 4-aminopyridine on Cognitive Performance and Motor Function of Patients With Multiple Sclerosis
Conditions: Multiple Sclerosis
Intervention: 4-aminopyridine, Placebo
Conditions: Multiple Sclerosis
Intervention: 4-aminopyridine, Placebo
August 6, 2019
18
NCT02166346
Completed
Completed
Safety and Efficacy of Sustained Release Dalfampridine in Transverse Myelitis (Re-Launch)
Conditions: Transverse Myelitis; Neuromyelitis Optica; Idiopathic Transverse Myelitis; Myelitis NOS
Intervention: Dalfampridine, Placebo
Conditions: Transverse Myelitis; Neuromyelitis Optica; Idiopathic Transverse Myelitis; Myelitis NOS
Intervention: Dalfampridine, Placebo
March 14, 2018
19
NCT01811706
Completed
Completed
Dalfampridine and Gait in Spinocerebellar Ataxias
Conditions: Spinocerebellar Ataxias Type 1; Spinocerebellar Ataxias Type 2; Spinocerebellar Ataxias Type 3; Spinocerebellar Ataxias Type 6
Intervention: Dalfampridine, Placebo
Conditions: Spinocerebellar Ataxias Type 1; Spinocerebellar Ataxias Type 2; Spinocerebellar Ataxias Type 3; Spinocerebellar Ataxias Type 6
Intervention: Dalfampridine, Placebo
January 8, 2015
20
NCT02868567
Recruiting
Recruiting
Use of Dalfampridin in Primary Lateral Sclerosis
Conditions: Motor Neuron Disease, Upper
Intervention: Dalfampridine
Conditions: Motor Neuron Disease, Upper
Intervention: Dalfampridine
August 26, 2019
21
NCT01215084
Completed
Completed
A Pharmacokinetics (PK) and Safety Study of Oral Fampridine-PR 10 mg in Chinese, Japanese, and Caucasian Adult Healthy Volunteers
Conditions: Healthy
Intervention: BIIB041 (Fampridine-PR)
Conditions: Healthy
Intervention: BIIB041 (Fampridine-PR)
July 7, 2014
22
NCT02219932
Completed
Completed
Efficacy and Safety Study of Prolonged-Release Fampridine in Participants With Multiple Sclerosis
Conditions: Multiple Sclerosis
Intervention: Fampridine, Placebo
Conditions: Multiple Sclerosis
Intervention: Fampridine, Placebo
February 6, 2017
23
NCT01356940
Completed
Completed
A Placebo Controlled Trial of Dalfampridine ER for Ambulatory Activity in People With Multiple Sclerosis
Conditions: Multiple Sclerosis
Intervention: Dalfampridine ER, Placebo
Conditions: Multiple Sclerosis
Intervention: Dalfampridine ER, Placebo
October 3, 2018
24
NCT01975324
Completed
Completed
A New Medicine to Treat Nonarteritic Anterior Ischemic Optic Neuropathy (NAION)
Conditions: Non Arteritic Ischemic Optic Neuropathy
Intervention: Dalfampridine, Placebo
Conditions: Non Arteritic Ischemic Optic Neuropathy
Intervention: Dalfampridine, Placebo
January 22, 2016
25
NCT02849782
Recruiting
Recruiting
Short and Long Term Multiple Outcomes in Persons With Multiple Sclerosis Treated by Fampridine.
Conditions: Multiple Sclerosis
Intervention: Fampridine
Conditions: Multiple Sclerosis
Intervention: Fampridine
July 17, 2018
26
NCT02271217
Completed
Completed
A Study to Evaluate the Efficacy and Safety of Two Dose Strengths of Dalfampridine Extended Release Tablets.
Conditions: Post-Ischemic Stroke
Intervention: Placebo, Dalfampridine-ER 7.5mg, Dalfampridine-ER 10mg
Conditions: Post-Ischemic Stroke
Intervention: Placebo, Dalfampridine-ER 7.5mg, Dalfampridine-ER 10mg
June 4, 2018
27
NCT03701581
Not yet recruiting
Not yet recruiting
4-aminopyridine Treatment for Nerve Injury
Conditions: Prostate Cancer
Intervention: 4-Aminopyridine, Placebo
Conditions: Prostate Cancer
Intervention: 4-Aminopyridine, Placebo
October 1, 2019
28
NCT01480076
Completed
Completed
Open-Label Study to Assess the Effect of Long-Term Prolonged-Release Fampridine (BIIB041) on Quality of Life as Reported by Participants With Multiple Sclerosis
Conditions: Multiple Sclerosis
Intervention: Fampridine
Conditions: Multiple Sclerosis
Intervention: Fampridine
February 14, 2017
29
NCT01645787
Completed
Completed
Short and Long Term Treatment With 4-AP in Ambulatory SMA Patients
Conditions: Spinal Muscular Atrophy
Intervention: 4-aminopyridine, Placebo
Conditions: Spinal Muscular Atrophy
Intervention: 4-aminopyridine, Placebo
May 17, 2016
30
NCT01444300
Completed
Completed
Dalfampridine for Imbalance in Multiple Sclerosis
Conditions: Multiple Sclerosis; Fatigue
Intervention: Dalfampridine, Placebo
Conditions: Multiple Sclerosis; Fatigue
Intervention: Dalfampridine, Placebo
May 16, 2014
31
NCT02006160
Completed
Completed
Effects of Dalfampridine on Cognition in Multiple Sclerosis
Conditions: Multiple Sclerosis
Intervention: Dalfampridine, Placebo
Conditions: Multiple Sclerosis
Intervention: Dalfampridine, Placebo
April 30, 2019
32
NCT01576354
Unknown status
Unknown status
Characterization of the Effects of Prolonged-release Fampridine on Ambulatory Function in Patients With Multiple Sclerosis
Conditions: Multiple Sclerosis
Intervention: Prolonged-release Fampridine, Placebo
Conditions: Multiple Sclerosis
Intervention: Prolonged-release Fampridine, Placebo
December 3, 2015
33
NCT01491022
Completed
Completed
A Randomized Trial to Evaluate Ampyra for Gait Impairment in Parkinson's Disease
Conditions: Parkinson's Disease
Intervention: Ampyra First, Then Placebo, Placebo First, Then Ampyra
Conditions: Parkinson's Disease
Intervention: Ampyra First, Then Placebo, Placebo First, Then Ampyra
December 5, 2017
34
NCT01917019
Completed
Completed
A Safety and Efficacy Study of Oral Prolonged-Release Fampridine (BIIB041) in Japanese Participants With Multiple Sclerosis
Conditions: Multiple Sclerosis, Remittent Progressive; Multiple Sclerosis, Primary Progressive; Relapsing-Remitting Multiple Sclerosis; Secondary Progressive Multiple Sclerosis; Multiple Sclerosis
Intervention: Placebo, BIIB041 (fampridine)
Conditions: Multiple Sclerosis, Remittent Progressive; Multiple Sclerosis, Primary Progressive; Relapsing-Remitting Multiple Sclerosis; Secondary Progressive Multiple Sclerosis; Multiple Sclerosis
Intervention: Placebo, BIIB041 (fampridine)
March 17, 2017
35
NCT02259361
Unknown status
Unknown status
Efficacy of Dalfampridine on Upper Extremity Function in Patients With MS
Conditions: Multiple Sclerosis
Intervention: Sustained-release Oral Dalfampridine, Placebo
Conditions: Multiple Sclerosis
Intervention: Sustained-release Oral Dalfampridine, Placebo
October 5, 2014
36
NCT01328379
Completed
Completed
Study of Fampridine-ER Tablets in Patients With Multiple Sclerosis
Conditions: Multiple Sclerosis
Intervention: Dalfampridine-ER 5mg, Dalfampridine-ER 10mg, Placebo
Conditions: Multiple Sclerosis
Intervention: Dalfampridine-ER 5mg, Dalfampridine-ER 10mg, Placebo
September 3, 2013
37
NCT01597297
Completed
Completed
Exploratory Study to Assess the Effect of Fampridine (BIIB041) on Walking Ability and Balance in Participants With Multiple Sclerosis.
Conditions: Multiple Sclerosis
Intervention: BIIB041 (PR Fampridine), Placebo
Conditions: Multiple Sclerosis
Intervention: BIIB041 (PR Fampridine), Placebo
January 5, 2017
38
NCT01605825
Completed
Completed
A Phase 2b Study of Dalfampridine 10mg Extended Release Tablet in Subjects With Chronic Deficits After Ischemic Stroke
Conditions: Ischemic Stroke
Intervention: Placebo/dalfampridine-ER, Dalfampridine-ER/placebo
Conditions: Ischemic Stroke
Intervention: Placebo/dalfampridine-ER, Dalfampridine-ER/placebo
December 18, 2015
39
NCT00053417
Completed
Completed
Safety and Efficacy Study of Oral Fampridine-SR in Patients With Multiple Sclerosis
Conditions: Multiple Sclerosis
Intervention: Placebo, 10 Milligram (mg) Fampridine-SR (4-aminopyridine, 4-AP), 15 Mg Fampridine-SR (4-aminopyridine, 4-AP), 20 Mg Fampridine-SR (4-aminopyridine, 4-AP)
Conditions: Multiple Sclerosis
Intervention: Placebo, 10 Milligram (mg) Fampridine-SR (4-aminopyridine, 4-AP), 15 Mg Fampridine-SR (4-aminopyridine, 4-AP), 20 Mg Fampridine-SR (4-aminopyridine, 4-AP)
August 3, 2011
40
NCT03658408
Withdrawn
Withdrawn
4-aminopyridine Treatment for Nerve Injury From Radical Retro-Pubic Prostatectomy
Conditions: Prostate Disease
Intervention: 4-aminopyridine, Placebo
Conditions: Prostate Disease
Intervention: 4-aminopyridine, Placebo
October 31, 2018
41
NCT01316055
Completed
Completed
Pharmacokinetics (PK) of Dalfampridine-ER 7.5 mg BID in Healthy Volunteers and Subjects With Mild or Moderate Renal Impairment
Conditions: Renal Insufficiency
Intervention: Dalfampridine-ER
Conditions: Renal Insufficiency
Intervention: Dalfampridine-ER
October 9, 2012
42
NCT01532154
Terminated
Terminated
Fampridine Pregnancy Exposure Registry
Conditions: Multiple Sclerosis; Pregnancy
Intervention: Fampridine
Conditions: Multiple Sclerosis; Pregnancy
Intervention: Fampridine
October 17, 2016
43
NCT02656160
Completed
Completed
Effect of Dalfampridine (4-AP) on Genioglossus Muscle Activity in Healthy Adults
Conditions: Sleep Apnea, Obstructive
Intervention: Placebo, Dalfampridine
Conditions: Sleep Apnea, Obstructive
Intervention: Placebo, Dalfampridine
July 14, 2017
44
NCT02146534
Completed
Completed
Prolonged-release Fampridine as Adjunct Therapy to Active Motor Training in MS Patients
Conditions: Multiple Sclerosis
Intervention: Extended Release Fampridine, Placebo
Conditions: Multiple Sclerosis
Intervention: Extended Release Fampridine, Placebo
March 4, 2019
45
NCT02143167
Completed
Completed
Resistance Training and Amino Pyridine in Multiple Sclerosis
Conditions: Multiple Sclerosis
Intervention: SR-fampridine, Placebo
Conditions: Multiple Sclerosis
Intervention: SR-fampridine, Placebo
August 22, 2018
46
NCT03164018
Completed
Completed
Fampridine in MS Patients: A Cognition, Fatigue, Depression and Quality of Life Analysis
Conditions: Multiple Sclerosis
Intervention: Fampridine
Conditions: Multiple Sclerosis
Intervention: Fampridine
February 13, 2019
47
NCT00056810
Completed
Completed
Assessment of Chronic Guillain-Barre Syndrome Improvement With Use of 4-aminopyridine
Conditions: Guillain-Barre Syndrome
Intervention: 4-aminopyridine (4-AP)
Conditions: Guillain-Barre Syndrome
Intervention: 4-aminopyridine (4-AP)
March 24, 2015
48
NCT01468350
Completed
Completed
Safety and Tolerability of Dalfampridine in Subjects With Cerebral Palsy
Conditions: Cerebral Palsy (CP)
Intervention: Dalfampridine-ER 10mg, Placebo
Conditions: Cerebral Palsy (CP)
Intervention: Dalfampridine-ER 10mg, Placebo
May 22, 2014
49
NCT04026568
Not yet recruiting
Not yet recruiting
A Single Dose Pharmaco-Diagnostic for Peripheral Nerve Continuity After Trauma
Conditions: Nerve Injury
Intervention: 4-Aminopyridine, Placebo Oral Tablet
Conditions: Nerve Injury
Intervention: 4-Aminopyridine, Placebo Oral Tablet
December 10, 2019
50
NCT01543750
Unknown status
Unknown status
4-Aminopyridine in Episodic Ataxia Type 2
Conditions: Episodic Ataxia Type 2
Intervention: 4-Aminopyridine, Placebo
Conditions: Episodic Ataxia Type 2
Intervention: 4-Aminopyridine, Placebo
February 7, 2014
Last Updated
The last updated date is the most recent date when changes to a clinical trial were
submitted to ClinicalTrials.gov. There is often a delay of a few days before the
updated trial is available on the clinical trials website.
Specify a From date to find the most recently changed trials. Specify both From and To dates to find trials changed during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
Specify a From date to find the most recently changed trials. Specify both From and To dates to find trials changed during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
First Received
The first received date is the date when the clinical trial was first submitted
to ClinicalTrials.gov. There is often a delay of a few days before the
trial is available on the clinical trials website.
Clinical trial records are often updated after they have been published. The first received, last updated, start, and end dates are all displayed in the full text view of the clinical trial.
Specify a From date to find the most recent trials. Specify both From and To dates to find trials submitted during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
Clinical trial records are often updated after they have been published. The first received, last updated, start, and end dates are all displayed in the full text view of the clinical trial.
Specify a From date to find the most recent trials. Specify both From and To dates to find trials submitted during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
Safety Issue
If selected, restricts search results to those studies which have
an outcome measure designated as a safety issue. Note that this is a
poor estimate of the safety of a treatment or intervention, but it is
all we have now.
Funded By
Studies are supported by one or more organizations called sponsors.
Support includes contributions of facilities, expertise, and/or financial resources.
All sponsors in the database have been assigned one of the following organization types:
National Institutes of Health (NIH)
Other U.S. Federal Agency - Food and Drug Administration (FDA), Centers for Disease Control and Prevention (CDC), Department of Veterans Affairs (VA), etc.
Industry - the pharmaceutical companies
University/Organization - all others, including community-based organizations
Click the check box to the left of each organization type that you wish to include in your search. You can select more than one organization type. If you do not select any type, all types will be included.
National Institutes of Health (NIH)
Other U.S. Federal Agency - Food and Drug Administration (FDA), Centers for Disease Control and Prevention (CDC), Department of Veterans Affairs (VA), etc.
Industry - the pharmaceutical companies
University/Organization - all others, including community-based organizations
Click the check box to the left of each organization type that you wish to include in your search. You can select more than one organization type. If you do not select any type, all types will be included.
Study Phase
Click the check box to the left of each study phase that you wish to include in your search. You can select more than one study phase. If you do not select a any phase, all phases will be included.
Most clinical trials are designated as phase 1, 2, 3, or 4, based on the type of questions
that study is seeking to answer:
In Phase 1 (Phase I) clinical trials, researchers test a new drug or treatment in a small group of people (20-80) for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
In Phase 2 (Phase II) clinical trials, the study drug or treatment is given to a larger group of people (100-300) to see if it is effective and to further evaluate its safety.
In Phase 3 (Phase III) clinical trials, the study drug or treatment is given to large groups of people (1,000-3,000) to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
In Phase 4 (Phase IV) clinical trials, post marketing studies delineate additional information including the drug's risks, benefits, and optimal use.
These phases are defined by the Food and Drug Administration in the Code of Federal Regulations.
In Phase 1 (Phase I) clinical trials, researchers test a new drug or treatment in a small group of people (20-80) for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
In Phase 2 (Phase II) clinical trials, the study drug or treatment is given to a larger group of people (100-300) to see if it is effective and to further evaluate its safety.
In Phase 3 (Phase III) clinical trials, the study drug or treatment is given to large groups of people (1,000-3,000) to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
In Phase 4 (Phase IV) clinical trials, post marketing studies delineate additional information including the drug's risks, benefits, and optimal use.
These phases are defined by the Food and Drug Administration in the Code of Federal Regulations.
Click the check box to the left of each study phase that you wish to include in your search. You can select more than one study phase. If you do not select a any phase, all phases will be included.
Age Group
Studies may be designed for participants of particular ages:
Children (birth-17 yrs old)
Adults (18-65 yrs old)
Senior (66+ yrs old)
Click the check box to the left of each age group that you wish to include in your search. You can select more than one age group. If you do not select a any group, all groups will be included.
Children (birth-17 yrs old)
Adults (18-65 yrs old)
Senior (66+ yrs old)
Click the check box to the left of each age group that you wish to include in your search. You can select more than one age group. If you do not select a any group, all groups will be included.
Gender
Searches can be restricted to studies which accept female or male participants.
Location Terms
If you are interested in a specific city (such as Los Angeles) or facility
name (such as the Mayo Clinic), enter it as a location term. Not all studies
include this level of detail, but if they do, this will find them.
Countries and States
Trials are often conducted at many locations around the world.
Select up to three locations to find trials conducted in
specific countries. Some countries (currently limited to the
United States, Canada, and Australia), locations can be narrowed
further by selecting a state.
Study IDs
Each trial is assigned one or more identification numbers by the institute, agency,
or organization sponsoring the trial. In addition, clinical trials assigns a
unique NCT identifier of the form NCTxxxxxxxx where each x is a numeric digit.
Use this box to search for a trial by NCT identifier or any other study
identification numbers.
Examples:
Examples:
NCT00001789
97-h-0197
ia0006
actg 076
97-h-0197
ia0006
actg 076
Sponsor (Lead)
Use this box to specify the name of an institute, organization, or company that is
conducting a trial.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
A search in this area will check only the sponsor field. To also look for collaborators, use the Sponsor/Collaborators search box.
When the Exact Match checkbox is checked, the sponsor name in the study must exactly match the sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
A search in this area will check only the sponsor field. To also look for collaborators, use the Sponsor/Collaborators search box.
When the Exact Match checkbox is checked, the sponsor name in the study must exactly match the sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
Sponsor/Collaborators
Use this box to specify institutes, organizations, or companies that are
conducting or otherwise supporting a trial.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
Searching this area will look in both the sponsor field and in the collaborators field. To only look in the sponsor field, use the Sponsor (Lead) search box.
When the Exact Match checkbox is checked, the name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
Searching this area will look in both the sponsor field and in the collaborators field. To only look in the sponsor field, use the Sponsor (Lead) search box.
When the Exact Match checkbox is checked, the name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
Outcome Measures
Use this box to specify an outcome measure used to evaluate trial results.
Examples:
weight loss
heart failure
suicide
Outcome measures are used to evaluate trial results. For example, an obesity treatment
might be evaluated by a measure of weight loss after 6 months. Measures can also be used
to quantify side effects, such as number of myocardial infarctions,
number of patients with heart arrhythmia, number of suicides, etc.
Use this box to specify an outcome measure used to evaluate trial results.
Examples:
weight loss
heart failure
suicide
Interventions
Use this box to specify drugs, devices, procedures, or vaccines used in a trial.
Examples:
clofibrate
cyclosporine
vitamin e
Interventions refer to the drug, vaccine, procedure, device, or other potential treatment being studied.
Interventions can also include less intrusive possibilities such as surveys, education, and interviews.
Use this box to specify drugs, devices, procedures, or vaccines used in a trial.
Examples:
clofibrate
cyclosporine
vitamin e
Conditions
Use this box to specify the conditions being studied.
Examples:
lupus
heart attack
leukemia
risk factors for breast cancer
Conditions usually refer to a disease, disorder, syndrome, illness, or injury. In ClinicalTrials.gov,
conditions include any health issue worth studying, such as lifespan, quality of life, health risks, etc.
Use this box to specify the conditions being studied.
Examples:
lupus
heart attack
leukemia
risk factors for breast cancer
Study Type
There are three types of studies available in ClinicalTrials.gov:
There are three types of studies available in ClinicalTrials.gov:
Interventional:
Observational:
Expanded Access:
Studies where individuals are assigned to receive specific interventions.
Participants may receive diagnostic, therapeutic or other types of interventions.
Assignment of the intervention may or may not be random.
Individuals are tracked and biomedical and/or health outcomes are assessed.
Observational:
Studies without an intervention.
Studies where biomedical and/or health outcomes are assessed in a pre-defined group of individuals.
Participants may receive diagnostic, therapeutic, or other interventions, but the investigator
does not assign specific interventions to the participants of the study.
Expanded Access:
Records describing the procedure for obtaining an experimental drug or device for patients who
are failing on currently available treatments for their condition and also are unable to
participate in ongoing clinical trials. Expanded Access records are used to register all
types of non-protocol access to experimental treatments, including protocol exception,
single-patient IND, treatment IND, compassionate use, emergency use, continued access and parallel track.
Study Results
Searches can be restricted to studies with or without results.
The inclusion of study results is a relatively new feature of ClinicalTrials.gov. Collection of results began in September of 2008. Almost all older studies and some newer studies do not include results. As time goes on, there will be more results available.
The inclusion of study results is a relatively new feature of ClinicalTrials.gov. Collection of results began in September of 2008. Almost all older studies and some newer studies do not include results. As time goes on, there will be more results available.
Recruitment Status
Also known as Enrollment Status.
Not all clinical trials in this database are accepting new participants. If you are looking for studies that are currently recruiting participants, will be recruiting in the future, or are about drugs that are available for expanded access, select Open Studies in the recruitment menu.
If you are interested in all trials, whether they are recruiting new participants or not, leave the menu with All Studies selected.
Trials may not be recruiting because they are full, completed, or halted for various reasons. In addition, some trials have very restrictive eligibility requirements and must seek participants by invitation only. To see these studies, Select Closed Studies in the recruitment menu.
Full list of all possible recruitment status values:
Open recruitment status values:
Closed recruitment status values:
Values are color coded (as shown) in the search results.
Not all clinical trials in this database are accepting new participants. If you are looking for studies that are currently recruiting participants, will be recruiting in the future, or are about drugs that are available for expanded access, select Open Studies in the recruitment menu.
If you are interested in all trials, whether they are recruiting new participants or not, leave the menu with All Studies selected.
Trials may not be recruiting because they are full, completed, or halted for various reasons. In addition, some trials have very restrictive eligibility requirements and must seek participants by invitation only. To see these studies, Select Closed Studies in the recruitment menu.
Full list of all possible recruitment status values:
Open recruitment status values:
Recruiting,
Not yet recruiting, or
Available for expanded access.
Not yet recruiting, or
Available for expanded access.
Closed recruitment status values:
Active, not recruiting,
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Search Terms
Use this box to specify general search terms found anywhere in the trial record.
Multiple terms can be separated by an AND (all uppercase).
Examples:
type ii diabetes
veterans affairs medical center
heart attacks in older adults
nhlbi AND heart disease
Cisplatin AND safety study
Multiple terms can be separated by an AND (all uppercase).
Examples:
type ii diabetes
veterans affairs medical center
heart attacks in older adults
nhlbi AND heart disease
Cisplatin AND safety study
Help for Searching clinical trials
Help Topics:
Basic Search:
On the Basic Search page, enter a word or word(s) that you want to use to find studies.
These may include diseases, interventions, and/or locations.
Medical terms are often several words long, such as Percutaneous Coronary Intervention. To only find studies where the words are together as a phrase, put the term in quotes (e.g., "Percutaneous Coronary Intervention"). If you search for a multi-word term without quotes, studies with all words together as a phrase will appear higher in the results list than studies where the words are separated and spread throughout the document. For example, a search for Heart Attack will list a study about,
A search for "Heart Attack" would not find the second study. Synonyms are known for some terms and are used where possible. For example, a search for Heart Attack will also find occurrences of Myocardial Infarction.
Medical terms are often several words long, such as Percutaneous Coronary Intervention. To only find studies where the words are together as a phrase, put the term in quotes (e.g., "Percutaneous Coronary Intervention"). If you search for a multi-word term without quotes, studies with all words together as a phrase will appear higher in the results list than studies where the words are separated and spread throughout the document. For example, a search for Heart Attack will list a study about,
Use of a Pacemaker Following a Heart Attack.
higher than the study,
Heart Defects and Transient Ischemic Attacks
A search for "Heart Attack" would not find the second study. Synonyms are known for some terms and are used where possible. For example, a search for Heart Attack will also find occurrences of Myocardial Infarction.
Advanced Search:
Many searches are a single term and can be performed with a few words in the
search box. But, sometimes you need more control. Click on the Advanced Search tab
(if starting a new search) or Refine Search tab (if modifying an existing search)
to show additional search fields.
The additional search fields can be used to limit your search results. Note that it is not necessary to fill in all the fields, only those that are needed for your search. If you are finding too few studies, consider clearing a field and searching again.
Search Terms:
Recruitment:
Interventions:
Outcomes Measures:
Sponsor/Collaborators:
Sponsor (Lead):
Study IDs:
Country/State:
Location Terms:
Gender:
Age Group:
Phase:
Funded By:
Safety Issue:
First Received:
Last Updated:
The additional search fields can be used to limit your search results. Note that it is not necessary to fill in all the fields, only those that are needed for your search. If you are finding too few studies, consider clearing a field and searching again.
Search Terms:
Performs a general search in all sections of the study record, including title,
description, conditions, interventions, locations, etc. Terms in this field are
searched the same as Basic Search.
Recruitment:
Limits search results to studies that are open or closed. New volunteers may be
able to participate in open studies, but not closed studies.
Open recruitment status values:
Closed recruitment status values:
Values are color coded (as shown) in the search results.
Study Results:Open recruitment status values:
Recruiting,
Not yet recruiting, or
Available for expanded access.
Not yet recruiting, or
Available for expanded access.
Closed recruitment status values:
Active, not recruiting,
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Values are color coded (as shown) in the search results.
Limits search results based on whether the study has results or not:
Study Type:
All Studies,
Studies With Results, or
Studies Without Results
The inclusion of Study Results is a new feature of ClinicalTrials.gov.
Only a few studies have results available.Studies With Results, or
Studies Without Results
Limits search results to any of the following study types:
Conditions:
Interventional,
Observational, or
Expanded Access
Observational, or
Expanded Access
Performs a search on fields describing the diseases or conditions being studied.
Interventions:
Performs a search on fields listing the drugs or interventions being studied.
Outcomes Measures:
Performs a search on fields listing the outcome measures used to quantify study results.
Sponsor/Collaborators:
Performs a search on fields listing the sponsor and collaborators of a study.
When the Exact Match checkbox is checked, the sponsor/collaborator name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck in the sponsor/collaborator field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
When the Exact Match checkbox is checked, the sponsor/collaborator name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck in the sponsor/collaborator field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Sponsor (Lead):
Performs a search on the sponsor field of a study.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the "sponsor" is decided by the data provider.
When the Exact Match checkbox is checked, the lead sponsor name in the study must exactly match the lead sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the "sponsor" is decided by the data provider.
When the Exact Match checkbox is checked, the lead sponsor name in the study must exactly match the lead sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Study IDs:
Performs a search on fields listing ID numbers.
Country/State:
Trials are often conducted at many locations around the world.
Select up to three locations to find trials conducted in
specific countries. Some countries (currently limited to the
United States, Canada, and Australia), locations can be narrowed
further by selecting a state (e.g., United States, Alabama).
Location Terms:
Finds studies in specific locations such as a city (Los Angeles) or facility (Mayo Clinic).
Not all studies include this level of detail, but if they do, this will find them.
Gender:
Limits search results to those studies that accept female or male participants.
Age Group:
Limits search results to those studies that include at least one of the specified age
ranges. More than one age group can be selected.
Phase:
Limits search results to studies that are labeled with at least one of the specified
phases. More than one Phase can be selected.
Funded By:
Limits search results to studies that have at least one sponsor of the specified types.
More than one sponsor type can be selected.
Safety Issue:
Limits search results to studies that have at least one outcome measure designated as a safety issue.
First Received:
Limits search results to studies that were received by clinical trials within a
specified date range. The "From" or "To" field can be left blank.
Last Updated:
Limits search results to studies that were modified within a
specified date range. The "From" or "To" field can be left blank.
Refine Search:
Searches display a list of studies found (List Results tab). If you are not content with
the search results, click on the Refine Search tab at the top of the list to modify your
search.
Add terms to empty fields to search within your current result. You can also add terms to fields that contain terms. For best results, use an AND (all upper case) as a separator between terms in the same field.
For example:
When you are done making changes, click Search to display the new results.
Add terms to empty fields to search within your current result. You can also add terms to fields that contain terms. For best results, use an AND (all upper case) as a separator between terms in the same field.
For example:
heart attack
heart attack AND aspirin
heart attack AND aspirin AND older adults
heart attack AND aspirin AND older adults AND California
heart attack AND aspirin
heart attack AND aspirin AND older adults
heart attack AND aspirin AND older adults AND California
When you are done making changes, click Search to display the new results.
Search Expressions:
Use AND (all upper case) to find study records that contain all terms connected by AND.
For example:
Use OR (all upper case) to find study records that contain either term connected by OR.
For example:
Use NOT (all upper case) to find study records that do not contain the term following NOT.
For example:
Likewise, AND, OR, NOT, and parentheses can be used to create more complicated search expressions.
For example:
Note that the use of AND and OR as logical operators can be confusing.
An appropriate search for a list such as,
To search for AND as a word, instead of using it as an operator, put it in quotes.
Likewise, you can quote OR, NOT, and parentheses.
For example:
prostate cancer AND radiation
heart disease AND stroke AND California
heart disease AND stroke AND California
Use OR (all upper case) to find study records that contain either term connected by OR.
For example:
Aspirin OR ibuprofen
heart disease OR heart attack
heart disease OR heart attack
Use NOT (all upper case) to find study records that do not contain the term following NOT.
For example:
Immunodeficiency NOT AIDS
Likewise, AND, OR, NOT, and parentheses can be used to create more complicated search expressions.
For example:
prostate cancer AND NOT ( radiation OR homeopathic remedies )
( heart disease OR heart attack ) AND ( stroke OR clot )
( heart disease OR heart attack ) AND ( stroke OR clot )
Note that the use of AND and OR as logical operators can be confusing.
An appropriate search for a list such as,
Ear, Nose, and Throat Conditions
is the expression
( Ear OR Nose OR Throat ) AND Conditions
Fortunately, search will do a pretty good job of finding the right studies either way.To search for AND as a word, instead of using it as an operator, put it in quotes.
Likewise, you can quote OR, NOT, and parentheses.