Clinical Trials: SEARCH[Study] TILT[Study:StudyFirstPostDate] AREA[ConditionSearch] Critical Limb Ischemia
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NCTID/Status
Study
Last Changed
201
NCT03430076
Recruiting
Recruiting
Polytetrafluoroethylen (PTFE) Vascular Prostheses With Heparin Bonded Luminal Surfaces vs Crude ePTFE
Conditions: Ischemia Lesions
Intervention: Revascularization, Propaten®, Crude PTFE
Conditions: Ischemia Lesions
Intervention: Revascularization, Propaten®, Crude PTFE
August 28, 2018
202
NCT00431314
Completed
Completed
Effect of Hemodialysis on Toe Pressure- and Finger Pressure and Skin Autofluorescence in Hemodialysis Patients
Conditions: End Stage Renal Disease
Conditions: End Stage Renal Disease
July 8, 2008
203
NCT00371371
Completed
Completed
Intra-arterial Stem Cell Therapy for Patients With Chronic Limb Ischemia (CLI)
Conditions: Peripheral Vascular Diseases; Arterial Occlusive Diseases; Leg Ulcer; Gangrene; Ischemia
Intervention: Bone Marrow Punction, BM-MNC Infusion, Placebo Infusion
Conditions: Peripheral Vascular Diseases; Arterial Occlusive Diseases; Leg Ulcer; Gangrene; Ischemia
Intervention: Bone Marrow Punction, BM-MNC Infusion, Placebo Infusion
December 12, 2012
204
NCT00904501
Completed
Completed
Bone Marrow Autograft in Limb Ischemia
Conditions: Peripheral Vascular Diseases
Intervention: Bone Marrow Harvest, Bone Marrow Harvest
Conditions: Peripheral Vascular Diseases
Intervention: Bone Marrow Harvest, Bone Marrow Harvest
March 5, 2016
205
NCT02993809
Unknown status
Unknown status
Autologous Transplantation of BM-ECs With Platelet-Rich Plasma Extract for the Treatment of Critical Limb Ischemia
Conditions: Leg Ulcer; Diabetic Foot; Gangrene; Peripheral Vascular Disease; Ischemia
Intervention: BM-ECs And PRPE, BM-ECs
Conditions: Leg Ulcer; Diabetic Foot; Gangrene; Peripheral Vascular Disease; Ischemia
Intervention: BM-ECs And PRPE, BM-ECs
December 13, 2016
206
NCT01216865
Unknown status
Unknown status
Umbilical Cord Mesenchymal Stem Cells Injection for Diabetic Foot
Conditions: Diabetic Foot; Critical Limb Ischemia; Mesenchymal Stem Cells; Umbilical Cord
Intervention: Umbilical Cord Mesenchymal Stem Cells, Standard Therapy
Conditions: Diabetic Foot; Critical Limb Ischemia; Mesenchymal Stem Cells; Umbilical Cord
Intervention: Umbilical Cord Mesenchymal Stem Cells, Standard Therapy
October 12, 2010
207
NCT03505931
Not yet recruiting
Not yet recruiting
Korean Multicenter Registry of ELUVIA Stent for Femoropopliteal Artery Disease (K-ELUVIA Registry)
Conditions: Symptomatic Peripheral Artery Disease With Femoropopliteal Lesions; Moderate or Severe Claudication (Rutherford Category 2 or 3); Critical Limb Ischemia (Rutherford Category 4 or 5)
Intervention: Implantation Of Eluvia Stent
Conditions: Symptomatic Peripheral Artery Disease With Femoropopliteal Lesions; Moderate or Severe Claudication (Rutherford Category 2 or 3); Critical Limb Ischemia (Rutherford Category 4 or 5)
Intervention: Implantation Of Eluvia Stent
April 13, 2018
208
NCT00533104
Completed
Completed
Cell Therapy in Chronic Limb Ischemia
Conditions: Peripheral Vascular Diseases
Intervention: BM-MNC Preparation, PB-MNC Preparation
Conditions: Peripheral Vascular Diseases
Intervention: BM-MNC Preparation, PB-MNC Preparation
February 5, 2009
209
NCT02758847
Recruiting
Recruiting
Evaluation of Paclitaxel in Patients With CLI and Femoropopliteal Occlusive Disease Treated With DCB Angioplasty
Conditions: Ischemia
Intervention: Angiogram, Medtronic DCB (paclitaxel)/stent, Angiogram, Bard DCB (paclitaxel)/stent
Conditions: Ischemia
Intervention: Angiogram, Medtronic DCB (paclitaxel)/stent, Angiogram, Bard DCB (paclitaxel)/stent
January 8, 2019
210
NCT02563535
Unknown status
Unknown status
Evaluation of the Use of ACOTEC Drug-Eluting Balloon Litos ® in Below-The-Knee Arteries to Treat Critical Limb Ischemia
Conditions: Peripheral Artery Disease
Conditions: Peripheral Artery Disease
September 28, 2015
211
NCT02239419
Unknown status
Unknown status
Evaluation of Carbothera in the Treatment of Foot Ulcers
Conditions: Critical Lower Limb Ischemia; Critical Limb Ischemia; Foot Ulcer; Skin Ulceration
Intervention: CO2-Enriched Tap Water (Carbothera), Non-CO2-Enriched Tap Water
Conditions: Critical Lower Limb Ischemia; Critical Limb Ischemia; Foot Ulcer; Skin Ulceration
Intervention: CO2-Enriched Tap Water (Carbothera), Non-CO2-Enriched Tap Water
October 29, 2015
212
NCT00823225
Terminated
Terminated
Urokinase Therapy in Patients With Diabetic Foot Syndrome
Conditions: Diabetic Foot; Arterial Occlusive Disease; Ischemia
Intervention: Standard Therapy, Urokinase
Conditions: Diabetic Foot; Arterial Occlusive Disease; Ischemia
Intervention: Standard Therapy, Urokinase
March 12, 2015
213
NCT02915796
Unknown status
Unknown status
Autologous CD133(+) Cells as an Adjuvant to Below the Knee Percutaneous Transluminal Angioplasty
Conditions: Peripheral Arterial Disease
Intervention: G-CSF + CD133(+) Cells, G-CSF, Percutaneous Transluminal Angioplasty (PTA), Placebo Infusion
Conditions: Peripheral Arterial Disease
Intervention: G-CSF + CD133(+) Cells, G-CSF, Percutaneous Transluminal Angioplasty (PTA), Placebo Infusion
September 27, 2016
214
NCT03970538
Not yet recruiting
Not yet recruiting
Percutaneous Deep Vein Arterialization for the Treatment of Late-Stage Chronic Limb-Threatening Ischemia: the PROMISE II Trial
Conditions: Critical Limb Ischemia; Critical Lower Limb Ischemia; Peripheral Artery Disease; Peripheral Arterial Disease
Intervention: LimFlow System
Conditions: Critical Limb Ischemia; Critical Lower Limb Ischemia; Peripheral Artery Disease; Peripheral Arterial Disease
Intervention: LimFlow System
October 2, 2019
215
NCT03845543
Not yet recruiting
Not yet recruiting
Belgian-Italian Trial to Evaluate the Efficacy and Safety of Below The Knee (BTK) Treatment With the Luminor 14 Paclitaxel Coated Percutaneous Transluminal Angioplasty Balloon Catheter of iVascular
Conditions: Peripheral Arterial Disease
Conditions: Peripheral Arterial Disease
February 18, 2019
216
NCT00221143
Completed
Completed
Stem Cell Study for Patients With Leg Ulcer/Gangrene
Conditions: Leg Pain; Ulcer; Gangrene; Ischemia; Peripheral Vascular Diseases
Intervention: Autologous Peripheral Blood CD34 Positive Cell Therapy
Conditions: Leg Pain; Ulcer; Gangrene; Ischemia; Peripheral Vascular Diseases
Intervention: Autologous Peripheral Blood CD34 Positive Cell Therapy
February 6, 2009
217
NCT00718991
Terminated
Terminated
EXCimEr Laser for Long lENgTh Lesions in Below-The-Knee Arteries Study
Conditions: Peripheral Arterial Occlusive Disease
Intervention: Spectranetics Turbo Elite™ Excimer Laser Catheter
Conditions: Peripheral Arterial Occlusive Disease
Intervention: Spectranetics Turbo Elite™ Excimer Laser Catheter
March 6, 2015
218
NCT00596752
Completed
Completed
Alprostadil in Peripheral Arterial Occlusive Disease (PAOD) Stage IV
Conditions: Peripheral Arterial Occlusive Disease
Intervention: Alprostadil, Placebo
Conditions: Peripheral Arterial Occlusive Disease
Intervention: Alprostadil, Placebo
March 8, 2018
219
NCT00721006
Completed
Completed
Phase II Combination Stem Cell Therapy for the Treatment of Severe Leg Ischemia
Conditions: Critical Limb Ischemia; Severe Leg Ischemia; Peripheral Artery Disease; Peripheral Vascular Disease
Intervention: MESENDO, Placebo
Conditions: Critical Limb Ischemia; Severe Leg Ischemia; Peripheral Artery Disease; Peripheral Vascular Disease
Intervention: MESENDO, Placebo
May 7, 2014
220
NCT02110251
Terminated
Terminated
Exercise Therapy With Risk Factor Management and Life Style Coaching After Vascular Intervention for Patients With Peripheral Arterial Disease
Conditions: Peripheral Arterial Disease, Rutherford 4 and 5 With Possibility to Improve Vascularization
Intervention: Supervised Exercise Therapy
Conditions: Peripheral Arterial Disease, Rutherford 4 and 5 With Possibility to Improve Vascularization
Intervention: Supervised Exercise Therapy
July 23, 2019
221
NCT04110327
Not yet recruiting
Not yet recruiting
An All-Comers Observational Study of the MicroStent™ Peripheral Vascular Stent System in Subjects With Peripheral Arterial Disease
Conditions: Peripheral Arterial Disease; Peripheral Artery Disease; Critical Limb Ischemia; Critical Lower Limb Ischemia
Intervention: MicroStent
Conditions: Peripheral Arterial Disease; Peripheral Artery Disease; Critical Limb Ischemia; Critical Lower Limb Ischemia
Intervention: MicroStent
September 27, 2019
222
NCT03253328
Recruiting
Recruiting
N-Acetyl-Cysteine (NAC) for Healing of Amputation Stumps in the Setting of Diabetes
Conditions: Diabetes Mellitus; Critical Limb Ischemia; Lower Limb Amputation Knee; Peripheral Arterial Disease
Intervention: Active Arm N-acetyl Cysteine (NAC), Placebo Arm
Conditions: Diabetes Mellitus; Critical Limb Ischemia; Lower Limb Amputation Knee; Peripheral Arterial Disease
Intervention: Active Arm N-acetyl Cysteine (NAC), Placebo Arm
March 27, 2019
223
NCT02864654
Unknown status
Unknown status
Effectiveness and Safety of Adipose-Derived Regenerative Cells for the Treatment of Critical Lower Limb Ischemia
Conditions: Critical Limb Ischemia; Arteriosclerosis Obliterans; Peripheral Arterial Disease; Thromboangiitis Obliterans; Diabetic Angiopathies
Intervention: ADRC Injection, ADRC Isolation, Liposuction
Conditions: Critical Limb Ischemia; Arteriosclerosis Obliterans; Peripheral Arterial Disease; Thromboangiitis Obliterans; Diabetic Angiopathies
Intervention: ADRC Injection, ADRC Isolation, Liposuction
August 11, 2016
224
NCT04058626
Recruiting
Recruiting
TEsting for Arterial Disease in Diabetes (TrEAD) Study
Conditions: Diabetic Foot; Peripheral Arterial Disease; Diabetic Foot Ulcer; Peripheral Vascular Diseases; Peripheral Artery Disease; Critical Limb Ischemia; Critical Lower Limb Ischemia
Intervention: Transcutaneous Pressure Of Oxygen (TcPO2), Toe Brachial Pressure Index (TBPI), Podiatry Ankle Duplex Scan (PAD-scan), Duplex Assist, Ankle Brachial Pressure Index (ABPI)
Conditions: Diabetic Foot; Peripheral Arterial Disease; Diabetic Foot Ulcer; Peripheral Vascular Diseases; Peripheral Artery Disease; Critical Limb Ischemia; Critical Lower Limb Ischemia
Intervention: Transcutaneous Pressure Of Oxygen (TcPO2), Toe Brachial Pressure Index (TBPI), Podiatry Ankle Duplex Scan (PAD-scan), Duplex Assist, Ankle Brachial Pressure Index (ABPI)
August 14, 2019
225
NCT04027244
Recruiting
Recruiting
Leg Ischaemia Management Collaboration
Conditions: Peripheral Arterial Disease; Critical Limb Ischemia; Frailty; Cognitive Impairment; Coronary Artery Disease
Conditions: Peripheral Arterial Disease; Critical Limb Ischemia; Frailty; Cognitive Impairment; Coronary Artery Disease
July 18, 2019
226
NCT01942941
Completed
Completed
Peripheral Vascular Disease and Nerve Stimulation
Conditions: Critical Limb Ischaemia; Claudication; Ulcers; Varicose Veins; Post Angioplasty
Intervention: Geko™ Electrical Stimulation
Conditions: Critical Limb Ischaemia; Claudication; Ulcers; Varicose Veins; Post Angioplasty
Intervention: Geko™ Electrical Stimulation
July 22, 2019
227
NCT04100681
Recruiting
Recruiting
Intermittent Negative Pressure; Impact on Peripheral Artery Disease and Intermittent Claudication
Conditions: Peripheral Vascular Disease; Intermittent Claudication; Walking, Difficulty; Critical Limb Ischemia; Ischemia Limb
Intervention: Active FlowOx™, Sham FlowOx™ (Placebo)
Conditions: Peripheral Vascular Disease; Intermittent Claudication; Walking, Difficulty; Critical Limb Ischemia; Ischemia Limb
Intervention: Active FlowOx™, Sham FlowOx™ (Placebo)
September 24, 2019
228
NCT03448029
Recruiting
Recruiting
RECCORD (Recording Courses of Vascular Diseases) Registry
Conditions: Vascular Diseases; Peripheral Artery Disease; Claudication; Critical Limb Ischemia; Diabetic Foot
Conditions: Vascular Diseases; Peripheral Artery Disease; Claudication; Critical Limb Ischemia; Diabetic Foot
January 22, 2019
229
NCT02395744
Completed
Completed
The COPPER-B Trial
Conditions: Cardiovascular Diseases; Peripheral Vascular Disease; Arterial Occlusive Diseases; Peripheral Arterial Disease; Critical Limb Ischemia
Intervention: Paclitaxel Administration Using The OPC
Conditions: Cardiovascular Diseases; Peripheral Vascular Disease; Arterial Occlusive Diseases; Peripheral Arterial Disease; Critical Limb Ischemia
Intervention: Paclitaxel Administration Using The OPC
February 24, 2017
230
NCT04175197
Not yet recruiting
Not yet recruiting
LegDeb2 Global Registry for Use of Legflow in Peripheral Arteries
Conditions: Peripheral Arterial Disease; Superficial Femoral Artery Stenosis; Iliac Artery Stenosis; Arterial Occlusive Diseases; Popliteal Artery Stenosis; Critical Limb Ischemia
Intervention: Drug Coated Balloon
Conditions: Peripheral Arterial Disease; Superficial Femoral Artery Stenosis; Iliac Artery Stenosis; Arterial Occlusive Diseases; Popliteal Artery Stenosis; Critical Limb Ischemia
Intervention: Drug Coated Balloon
November 21, 2019
231
NCT03594344
Recruiting
Recruiting
Additional Hyperbaric Oxygen After Lower Extremity Amputation
Conditions: Diabetes Mellitus; Claudication, Intermittent; Critical Limb Ischemia; Osteomyelitis; Amputation; Lower Extremity Ulcer; Diabetic Angiopathy; Diabetic Neuropathies; Diabetic Foot
Intervention: Hyperbaric Oxygen Therapy
Conditions: Diabetes Mellitus; Claudication, Intermittent; Critical Limb Ischemia; Osteomyelitis; Amputation; Lower Extremity Ulcer; Diabetic Angiopathy; Diabetic Neuropathies; Diabetic Foot
Intervention: Hyperbaric Oxygen Therapy
January 18, 2019
232
NCT00282646
Completed
Completed
Safety and Feasibility Study of Autologous Bone Marrow Cell Transplantation in Patients With Peripheral Arterial Occlusive Disease (PAOD)
Conditions: Arterial Occlusive Diseases
Conditions: Arterial Occlusive Diseases
August 23, 2011
233
NCT00539266
Unknown status
Unknown status
Autologous Bone Marrow-derived Mononuclear Cells for Therapeutic Arteriogenesis in Patients With Limb Ischemia
Conditions: Intermittent Claudication; Peripheral Vascular Diseases
Intervention: Bone Marrow Derived Mononuclear Cells, Placebo
Conditions: Intermittent Claudication; Peripheral Vascular Diseases
Intervention: Bone Marrow Derived Mononuclear Cells, Placebo
July 5, 2011
234
NCT00300040
Terminated
Terminated
Safety/Feasibility Study of HBOC-201 in Amputation at/Below Knee From Critical Lower Limb Ischemia
Conditions: Peripheral Vascular Disease
Intervention: Hemoglobin Glutamer 250 - Bovine, 6% Hydroxyethylstarch
Conditions: Peripheral Vascular Disease
Intervention: Hemoglobin Glutamer 250 - Bovine, 6% Hydroxyethylstarch
May 15, 2008
235
NCT01630070
Completed
Completed
Single Arm Study With a Nitinol Self-Expanding Paclitaxel-Eluting Stent to Treat BTK Arteries
Conditions: Peripheral Arterial Disease
Intervention: Self-expandable Drug Eluting Stent
Conditions: Peripheral Arterial Disease
Intervention: Self-expandable Drug Eluting Stent
March 6, 2015
236
NCT01147419
Unknown status
Unknown status
Comparison of Stent and Prothesis Bypass in Superficial Femoral Artery
Conditions: Arterial Occlusive Diseases; Vascular Diseases
Intervention: Stent, Femoral-popliteal Bypass With Artificial Blood Vessel
Conditions: Arterial Occlusive Diseases; Vascular Diseases
Intervention: Stent, Femoral-popliteal Bypass With Artificial Blood Vessel
July 6, 2010
237
NCT02096757
Completed
Completed
The Use of Fish Oil to Reduce Inflammation Caused by a Peripheral Vascular Intervention
Conditions: Peripheral Arterial Disease
Conditions: Peripheral Arterial Disease
January 2, 2018
238
NCT03149913
Recruiting
Recruiting
Local Paclitaxel or Balloon Angioplasty Below the Knee
Conditions: Stenosis; Occlusion; Restenosis
Conditions: Stenosis; Occlusion; Restenosis
May 10, 2017
239
NCT02371785
Completed
Completed
Robotic-Assisted Peripheral Intervention for Peripheral Arterial Disease
Conditions: Peripheral Arterial Disease
Intervention: CorPath 200 System
Conditions: Peripheral Arterial Disease
Intervention: CorPath 200 System
March 18, 2019
240
NCT04066387
Completed
Completed
Characteristics and Prognosis of Patients With Critical Ischemia at High Risk of Amputation Managed by Endovascular Bypass: a Retrospective Study of 15 Patients
Conditions: Limb Ischemia
Conditions: Limb Ischemia
October 2, 2019
241
NCT00145262
Unknown status
Unknown status
TACT-NAGOYA: Therapeutic Angiogenesis Using Cell Transplantation
Conditions: Buerger Disease; Arteriosclerosis Obliterans
Intervention: Autologous Bone Marrow Mononuclear Cell Implantation
Conditions: Buerger Disease; Arteriosclerosis Obliterans
Intervention: Autologous Bone Marrow Mononuclear Cell Implantation
December 29, 2005
242
NCT02942966
Active, not recruiting
Active, not recruiting
Tack Optimized Balloon Angioplasty Study of the Tack Endovascular System® in Below the Knee Arteries
Conditions: Peripheral Arterial Disease
Intervention: Tack Endovascular System
Conditions: Peripheral Arterial Disease
Intervention: Tack Endovascular System
September 4, 2019
243
NCT00059644
Terminated
Terminated
Efficacy/Safety of Ecraprost in Lipid Emulsion for Treatment of Critical Leg Ischemia Due to Peripheral Arterial Disease
Conditions: Peripheral Vascular Disease
Intervention: Ecraprost In Lipid Emulsion
Conditions: Peripheral Vascular Disease
Intervention: Ecraprost In Lipid Emulsion
June 23, 2005
244
NCT01861327
Unknown status
Unknown status
The Use of Carbon Dioxide as a Contrast Media for Performing Endovascular Procedures
Conditions: Critical Lower Limb Ischemia; Abdominal Aortic Aneurysms
Intervention: CO2, Iodine Contrast Media
Conditions: Critical Lower Limb Ischemia; Abdominal Aortic Aneurysms
Intervention: CO2, Iodine Contrast Media
February 23, 2017
245
NCT03042572
Not yet recruiting
Not yet recruiting
Allogeneic Mesenchymal Stromal Cells for Angiogenesis and Neovascularization in No-option Ischemic Limbs
Conditions: Peripheral Arterial Disease; Cardiovascular Diseases; Vascular Diseases
Intervention: Allogeneic Mesenchymal Stromal Cell, Placebo
Conditions: Peripheral Arterial Disease; Cardiovascular Diseases; Vascular Diseases
Intervention: Allogeneic Mesenchymal Stromal Cell, Placebo
May 2, 2018
246
NCT02956993
Completed
Completed
Safety/Feasibility of Vonapanitase Following Angioplasty for Patients With Peripheral Artery Disease (PAD) Below the Knee (BTK)
Conditions: Peripheral Artery Disease
Intervention: Vonapanitase, Placebo
Conditions: Peripheral Artery Disease
Intervention: Vonapanitase, Placebo
April 30, 2019
247
NCT00516308
Terminated
Terminated
A Non-Randomized Study of the NightHawk Peripheral Plaque Excision System During Plaque Excision of Peripheral Arterial Disease
Conditions: Peripheral Vascular Diseases
Intervention: NightHawk
Conditions: Peripheral Vascular Diseases
Intervention: NightHawk
January 16, 2008
248
NCT00059657
Completed
Completed
Efficacy/Safety of Ecraprost in Lipid Emulsion for Treatment of Critical Leg Ischemia Due to Peripheral Arterial Disease
Conditions: Peripheral Vascular Disease
Intervention: Ecraprost In Lipid Emulsion
Conditions: Peripheral Vascular Disease
Intervention: Ecraprost In Lipid Emulsion
May 17, 2006
249
NCT00041925
Completed
Completed
Prevention of Autogenous Vein Graft Failure in Peripheral Artery Bypass Procedures
Conditions: Peripheral Vascular Diseases; Arterial Occlusive Diseases; Ischemia; Graft Occlusion, Vascular; Hyperplasia
Intervention: CGT003 (E2F Duplex Decoy)
Conditions: Peripheral Vascular Diseases; Arterial Occlusive Diseases; Ischemia; Graft Occlusion, Vascular; Hyperplasia
Intervention: CGT003 (E2F Duplex Decoy)
July 14, 2005
250
NCT04107298
Not yet recruiting
Not yet recruiting
Safety and Feasibility of Surmodics SUNDANCE™ Drug Coated Balloon
Conditions: Peripheral Arterial Disease; Critical Lower Limb Ischemia
Intervention: SUNDANCE™ Drug Coated Balloon
Conditions: Peripheral Arterial Disease; Critical Lower Limb Ischemia
Intervention: SUNDANCE™ Drug Coated Balloon
September 27, 2019
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These phases are defined by the Food and Drug Administration in the Code of Federal Regulations.
In Phase 1 (Phase I) clinical trials, researchers test a new drug or treatment in a small group of people (20-80) for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
In Phase 2 (Phase II) clinical trials, the study drug or treatment is given to a larger group of people (100-300) to see if it is effective and to further evaluate its safety.
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Examples:
NCT00001789
97-h-0197
ia0006
actg 076
97-h-0197
ia0006
actg 076
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It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
A search in this area will check only the sponsor field. To also look for collaborators, use the Sponsor/Collaborators search box.
When the Exact Match checkbox is checked, the sponsor name in the study must exactly match the sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
Sponsor/Collaborators
Use this box to specify institutes, organizations, or companies that are
conducting or otherwise supporting a trial.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
Searching this area will look in both the sponsor field and in the collaborators field. To only look in the sponsor field, use the Sponsor (Lead) search box.
When the Exact Match checkbox is checked, the name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
Searching this area will look in both the sponsor field and in the collaborators field. To only look in the sponsor field, use the Sponsor (Lead) search box.
When the Exact Match checkbox is checked, the name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
Outcome Measures
Use this box to specify an outcome measure used to evaluate trial results.
Examples:
weight loss
heart failure
suicide
Outcome measures are used to evaluate trial results. For example, an obesity treatment
might be evaluated by a measure of weight loss after 6 months. Measures can also be used
to quantify side effects, such as number of myocardial infarctions,
number of patients with heart arrhythmia, number of suicides, etc.
Use this box to specify an outcome measure used to evaluate trial results.
Examples:
weight loss
heart failure
suicide
Interventions
Use this box to specify drugs, devices, procedures, or vaccines used in a trial.
Examples:
clofibrate
cyclosporine
vitamin e
Interventions refer to the drug, vaccine, procedure, device, or other potential treatment being studied.
Interventions can also include less intrusive possibilities such as surveys, education, and interviews.
Use this box to specify drugs, devices, procedures, or vaccines used in a trial.
Examples:
clofibrate
cyclosporine
vitamin e
Conditions
Use this box to specify the conditions being studied.
Examples:
lupus
heart attack
leukemia
risk factors for breast cancer
Conditions usually refer to a disease, disorder, syndrome, illness, or injury. In ClinicalTrials.gov,
conditions include any health issue worth studying, such as lifespan, quality of life, health risks, etc.
Use this box to specify the conditions being studied.
Examples:
lupus
heart attack
leukemia
risk factors for breast cancer
Study Type
There are three types of studies available in ClinicalTrials.gov:
There are three types of studies available in ClinicalTrials.gov:
Interventional:
Observational:
Expanded Access:
Studies where individuals are assigned to receive specific interventions.
Participants may receive diagnostic, therapeutic or other types of interventions.
Assignment of the intervention may or may not be random.
Individuals are tracked and biomedical and/or health outcomes are assessed.
Observational:
Studies without an intervention.
Studies where biomedical and/or health outcomes are assessed in a pre-defined group of individuals.
Participants may receive diagnostic, therapeutic, or other interventions, but the investigator
does not assign specific interventions to the participants of the study.
Expanded Access:
Records describing the procedure for obtaining an experimental drug or device for patients who
are failing on currently available treatments for their condition and also are unable to
participate in ongoing clinical trials. Expanded Access records are used to register all
types of non-protocol access to experimental treatments, including protocol exception,
single-patient IND, treatment IND, compassionate use, emergency use, continued access and parallel track.
Study Results
Searches can be restricted to studies with or without results.
The inclusion of study results is a relatively new feature of ClinicalTrials.gov. Collection of results began in September of 2008. Almost all older studies and some newer studies do not include results. As time goes on, there will be more results available.
The inclusion of study results is a relatively new feature of ClinicalTrials.gov. Collection of results began in September of 2008. Almost all older studies and some newer studies do not include results. As time goes on, there will be more results available.
Recruitment Status
Also known as Enrollment Status.
Not all clinical trials in this database are accepting new participants. If you are looking for studies that are currently recruiting participants, will be recruiting in the future, or are about drugs that are available for expanded access, select Open Studies in the recruitment menu.
If you are interested in all trials, whether they are recruiting new participants or not, leave the menu with All Studies selected.
Trials may not be recruiting because they are full, completed, or halted for various reasons. In addition, some trials have very restrictive eligibility requirements and must seek participants by invitation only. To see these studies, Select Closed Studies in the recruitment menu.
Full list of all possible recruitment status values:
Open recruitment status values:
Closed recruitment status values:
Values are color coded (as shown) in the search results.
Not all clinical trials in this database are accepting new participants. If you are looking for studies that are currently recruiting participants, will be recruiting in the future, or are about drugs that are available for expanded access, select Open Studies in the recruitment menu.
If you are interested in all trials, whether they are recruiting new participants or not, leave the menu with All Studies selected.
Trials may not be recruiting because they are full, completed, or halted for various reasons. In addition, some trials have very restrictive eligibility requirements and must seek participants by invitation only. To see these studies, Select Closed Studies in the recruitment menu.
Full list of all possible recruitment status values:
Open recruitment status values:
Recruiting,
Not yet recruiting, or
Available for expanded access.
Not yet recruiting, or
Available for expanded access.
Closed recruitment status values:
Active, not recruiting,
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Search Terms
Use this box to specify general search terms found anywhere in the trial record.
Multiple terms can be separated by an AND (all uppercase).
Examples:
type ii diabetes
veterans affairs medical center
heart attacks in older adults
nhlbi AND heart disease
Cisplatin AND safety study
Multiple terms can be separated by an AND (all uppercase).
Examples:
type ii diabetes
veterans affairs medical center
heart attacks in older adults
nhlbi AND heart disease
Cisplatin AND safety study
Help for Searching clinical trials
Help Topics:
Basic Search:
On the Basic Search page, enter a word or word(s) that you want to use to find studies.
These may include diseases, interventions, and/or locations.
Medical terms are often several words long, such as Percutaneous Coronary Intervention. To only find studies where the words are together as a phrase, put the term in quotes (e.g., "Percutaneous Coronary Intervention"). If you search for a multi-word term without quotes, studies with all words together as a phrase will appear higher in the results list than studies where the words are separated and spread throughout the document. For example, a search for Heart Attack will list a study about,
A search for "Heart Attack" would not find the second study. Synonyms are known for some terms and are used where possible. For example, a search for Heart Attack will also find occurrences of Myocardial Infarction.
Medical terms are often several words long, such as Percutaneous Coronary Intervention. To only find studies where the words are together as a phrase, put the term in quotes (e.g., "Percutaneous Coronary Intervention"). If you search for a multi-word term without quotes, studies with all words together as a phrase will appear higher in the results list than studies where the words are separated and spread throughout the document. For example, a search for Heart Attack will list a study about,
Use of a Pacemaker Following a Heart Attack.
higher than the study,
Heart Defects and Transient Ischemic Attacks
A search for "Heart Attack" would not find the second study. Synonyms are known for some terms and are used where possible. For example, a search for Heart Attack will also find occurrences of Myocardial Infarction.
Advanced Search:
Many searches are a single term and can be performed with a few words in the
search box. But, sometimes you need more control. Click on the Advanced Search tab
(if starting a new search) or Refine Search tab (if modifying an existing search)
to show additional search fields.
The additional search fields can be used to limit your search results. Note that it is not necessary to fill in all the fields, only those that are needed for your search. If you are finding too few studies, consider clearing a field and searching again.
Search Terms:
Recruitment:
Interventions:
Outcomes Measures:
Sponsor/Collaborators:
Sponsor (Lead):
Study IDs:
Country/State:
Location Terms:
Gender:
Age Group:
Phase:
Funded By:
Safety Issue:
First Received:
Last Updated:
The additional search fields can be used to limit your search results. Note that it is not necessary to fill in all the fields, only those that are needed for your search. If you are finding too few studies, consider clearing a field and searching again.
Search Terms:
Performs a general search in all sections of the study record, including title,
description, conditions, interventions, locations, etc. Terms in this field are
searched the same as Basic Search.
Recruitment:
Limits search results to studies that are open or closed. New volunteers may be
able to participate in open studies, but not closed studies.
Open recruitment status values:
Closed recruitment status values:
Values are color coded (as shown) in the search results.
Study Results:Open recruitment status values:
Recruiting,
Not yet recruiting, or
Available for expanded access.
Not yet recruiting, or
Available for expanded access.
Closed recruitment status values:
Active, not recruiting,
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Values are color coded (as shown) in the search results.
Limits search results based on whether the study has results or not:
Study Type:
All Studies,
Studies With Results, or
Studies Without Results
The inclusion of Study Results is a new feature of ClinicalTrials.gov.
Only a few studies have results available.Studies With Results, or
Studies Without Results
Limits search results to any of the following study types:
Conditions:
Interventional,
Observational, or
Expanded Access
Observational, or
Expanded Access
Performs a search on fields describing the diseases or conditions being studied.
Interventions:
Performs a search on fields listing the drugs or interventions being studied.
Outcomes Measures:
Performs a search on fields listing the outcome measures used to quantify study results.
Sponsor/Collaborators:
Performs a search on fields listing the sponsor and collaborators of a study.
When the Exact Match checkbox is checked, the sponsor/collaborator name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck in the sponsor/collaborator field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
When the Exact Match checkbox is checked, the sponsor/collaborator name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck in the sponsor/collaborator field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Sponsor (Lead):
Performs a search on the sponsor field of a study.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the "sponsor" is decided by the data provider.
When the Exact Match checkbox is checked, the lead sponsor name in the study must exactly match the lead sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the "sponsor" is decided by the data provider.
When the Exact Match checkbox is checked, the lead sponsor name in the study must exactly match the lead sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Study IDs:
Performs a search on fields listing ID numbers.
Country/State:
Trials are often conducted at many locations around the world.
Select up to three locations to find trials conducted in
specific countries. Some countries (currently limited to the
United States, Canada, and Australia), locations can be narrowed
further by selecting a state (e.g., United States, Alabama).
Location Terms:
Finds studies in specific locations such as a city (Los Angeles) or facility (Mayo Clinic).
Not all studies include this level of detail, but if they do, this will find them.
Gender:
Limits search results to those studies that accept female or male participants.
Age Group:
Limits search results to those studies that include at least one of the specified age
ranges. More than one age group can be selected.
Phase:
Limits search results to studies that are labeled with at least one of the specified
phases. More than one Phase can be selected.
Funded By:
Limits search results to studies that have at least one sponsor of the specified types.
More than one sponsor type can be selected.
Safety Issue:
Limits search results to studies that have at least one outcome measure designated as a safety issue.
First Received:
Limits search results to studies that were received by clinical trials within a
specified date range. The "From" or "To" field can be left blank.
Last Updated:
Limits search results to studies that were modified within a
specified date range. The "From" or "To" field can be left blank.
Refine Search:
Searches display a list of studies found (List Results tab). If you are not content with
the search results, click on the Refine Search tab at the top of the list to modify your
search.
Add terms to empty fields to search within your current result. You can also add terms to fields that contain terms. For best results, use an AND (all upper case) as a separator between terms in the same field.
For example:
When you are done making changes, click Search to display the new results.
Add terms to empty fields to search within your current result. You can also add terms to fields that contain terms. For best results, use an AND (all upper case) as a separator between terms in the same field.
For example:
heart attack
heart attack AND aspirin
heart attack AND aspirin AND older adults
heart attack AND aspirin AND older adults AND California
heart attack AND aspirin
heart attack AND aspirin AND older adults
heart attack AND aspirin AND older adults AND California
When you are done making changes, click Search to display the new results.
Search Expressions:
Use AND (all upper case) to find study records that contain all terms connected by AND.
For example:
Use OR (all upper case) to find study records that contain either term connected by OR.
For example:
Use NOT (all upper case) to find study records that do not contain the term following NOT.
For example:
Likewise, AND, OR, NOT, and parentheses can be used to create more complicated search expressions.
For example:
Note that the use of AND and OR as logical operators can be confusing.
An appropriate search for a list such as,
To search for AND as a word, instead of using it as an operator, put it in quotes.
Likewise, you can quote OR, NOT, and parentheses.
For example:
prostate cancer AND radiation
heart disease AND stroke AND California
heart disease AND stroke AND California
Use OR (all upper case) to find study records that contain either term connected by OR.
For example:
Aspirin OR ibuprofen
heart disease OR heart attack
heart disease OR heart attack
Use NOT (all upper case) to find study records that do not contain the term following NOT.
For example:
Immunodeficiency NOT AIDS
Likewise, AND, OR, NOT, and parentheses can be used to create more complicated search expressions.
For example:
prostate cancer AND NOT ( radiation OR homeopathic remedies )
( heart disease OR heart attack ) AND ( stroke OR clot )
( heart disease OR heart attack ) AND ( stroke OR clot )
Note that the use of AND and OR as logical operators can be confusing.
An appropriate search for a list such as,
Ear, Nose, and Throat Conditions
is the expression
( Ear OR Nose OR Throat ) AND Conditions
Fortunately, search will do a pretty good job of finding the right studies either way.To search for AND as a word, instead of using it as an operator, put it in quotes.
Likewise, you can quote OR, NOT, and parentheses.