Clinical Trials: SEARCH[STUDY] TILT[STUDY:STUDY-FIRST-POSTED] ( Critical Limb Ischemia [STUDY:DISEASE] )
#
NCTID/Status
Study
Last Changed
201
NCT03505931
Not yet recruiting
Not yet recruiting
Korean Multicenter Registry of ELUVIA Stent for Femoropopliteal Artery Disease (K-ELUVIA Registry)
Conditions: Symptomatic Peripheral Artery Disease With Femoropopliteal Lesions; Moderate or Severe Claudication (Rutherford Category 2 or 3); Critical Limb Ischemia (Rutherford Category 4 or 5)
Intervention: Implantation Of Eluvia Stent
Conditions: Symptomatic Peripheral Artery Disease With Femoropopliteal Lesions; Moderate or Severe Claudication (Rutherford Category 2 or 3); Critical Limb Ischemia (Rutherford Category 4 or 5)
Intervention: Implantation Of Eluvia Stent
April 13, 2018
202
NCT00533104
Completed
Completed
Cell Therapy in Chronic Limb Ischemia
Conditions: Peripheral Vascular Diseases
Intervention: BM-MNC Preparation, PB-MNC Preparation
Conditions: Peripheral Vascular Diseases
Intervention: BM-MNC Preparation, PB-MNC Preparation
February 5, 2009
203
NCT02758847
Recruiting
Recruiting
Evaluation of Paclitaxel in Patients With CLI and Femoropopliteal Occlusive Disease Treated With DCB Angioplasty
Conditions: Ischemia
Intervention: Angiogram, Medtronic DCB (paclitaxel)/stent, Angiogram, Bard DCB (paclitaxel)/stent
Conditions: Ischemia
Intervention: Angiogram, Medtronic DCB (paclitaxel)/stent, Angiogram, Bard DCB (paclitaxel)/stent
January 8, 2019
204
NCT02563535
Unknown status
Unknown status
Evaluation of the Use of ACOTEC Drug-Eluting Balloon Litos ® in Below-The-Knee Arteries to Treat Critical Limb Ischemia
Conditions: Peripheral Artery Disease
Intervention: DEB, PTA
Conditions: Peripheral Artery Disease
Intervention: DEB, PTA
September 28, 2015
205
NCT02239419
Unknown status
Unknown status
Evaluation of Carbothera in the Treatment of Foot Ulcers
Conditions: Critical Lower Limb Ischemia; Critical Limb Ischemia; Foot Ulcer; Skin Ulceration
Intervention: CO2-Enriched Tap Water (Carbothera), Non-CO2-Enriched Tap Water
Conditions: Critical Lower Limb Ischemia; Critical Limb Ischemia; Foot Ulcer; Skin Ulceration
Intervention: CO2-Enriched Tap Water (Carbothera), Non-CO2-Enriched Tap Water
October 29, 2015
206
NCT00823225
Terminated
Terminated
Urokinase Therapy in Patients With Diabetic Foot Syndrome
Conditions: Diabetic Foot; Arterial Occlusive Disease; Ischemia
Intervention: Standard Therapy, Urokinase
Conditions: Diabetic Foot; Arterial Occlusive Disease; Ischemia
Intervention: Standard Therapy, Urokinase
March 12, 2015
207
NCT02915796
Unknown status
Unknown status
Autologous CD133(+) Cells as an Adjuvant to Below the Knee Percutaneous Transluminal Angioplasty
Conditions: Peripheral Arterial Disease
Intervention: G-CSF + CD133(+) Cells, G-CSF, Percutaneous Transluminal Angioplasty (PTA), Placebo Infusion
Conditions: Peripheral Arterial Disease
Intervention: G-CSF + CD133(+) Cells, G-CSF, Percutaneous Transluminal Angioplasty (PTA), Placebo Infusion
September 27, 2016
208
NCT03845543
Not yet recruiting
Not yet recruiting
Belgian-Italian Trial to Evaluate the Efficacy and Safety of Below The Knee (BTK) Treatment With the Luminor 14 Paclitaxel Coated Percutaneous Transluminal Angioplasty Balloon Catheter of iVascular
Conditions: Peripheral Arterial Disease
Intervention: Luminor-14 Paclitaxel Eluting Balloon
Conditions: Peripheral Arterial Disease
Intervention: Luminor-14 Paclitaxel Eluting Balloon
February 18, 2019
209
NCT00221143
Completed
Completed
Stem Cell Study for Patients With Leg Ulcer/Gangrene
Conditions: Leg Pain; Ulcer; Gangrene; Ischemia; Peripheral Vascular Diseases
Intervention: Autologous Peripheral Blood CD34 Positive Cell Therapy
Conditions: Leg Pain; Ulcer; Gangrene; Ischemia; Peripheral Vascular Diseases
Intervention: Autologous Peripheral Blood CD34 Positive Cell Therapy
February 6, 2009
210
NCT00718991
Terminated
Terminated
EXCimEr Laser for Long lENgTh Lesions in Below-The-Knee Arteries Study
Conditions: Peripheral Arterial Occlusive Disease
Intervention: Spectranetics Turbo Elite™ Excimer Laser Catheter
Conditions: Peripheral Arterial Occlusive Disease
Intervention: Spectranetics Turbo Elite™ Excimer Laser Catheter
March 6, 2015
211
NCT00596752
Completed
Completed
Alprostadil in Peripheral Arterial Occlusive Disease (PAOD) Stage IV
Conditions: Peripheral Arterial Occlusive Disease
Intervention: Alprostadil, Placebo
Conditions: Peripheral Arterial Occlusive Disease
Intervention: Alprostadil, Placebo
March 8, 2018
212
NCT00721006
Completed
Completed
Phase II Combination Stem Cell Therapy for the Treatment of Severe Leg Ischemia
Conditions: Critical Limb Ischemia; Severe Leg Ischemia; Peripheral Artery Disease; Peripheral Vascular Disease
Intervention: MESENDO, Placebo
Conditions: Critical Limb Ischemia; Severe Leg Ischemia; Peripheral Artery Disease; Peripheral Vascular Disease
Intervention: MESENDO, Placebo
May 7, 2014
213
NCT02110251
Terminated
Terminated
Exercise Therapy With Risk Factor Management and Life Style Coaching After Vascular Intervention for Patients With Peripheral Arterial Disease
Conditions: Peripheral Arterial Disease, Rutherford 4 and 5 With Possibility to Improve Vascularization
Intervention: Supervised Exercise Therapy
Conditions: Peripheral Arterial Disease, Rutherford 4 and 5 With Possibility to Improve Vascularization
Intervention: Supervised Exercise Therapy
July 23, 2019
214
NCT03253328
Recruiting
Recruiting
N-Acetyl-Cysteine (NAC) for Healing of Amputation Stumps in the Setting of Diabetes
Conditions: Diabetes Mellitus; Critical Limb Ischemia; Lower Limb Amputation Knee; Peripheral Arterial Disease
Intervention: Active Arm N-acetyl Cysteine (NAC), Placebo Arm
Conditions: Diabetes Mellitus; Critical Limb Ischemia; Lower Limb Amputation Knee; Peripheral Arterial Disease
Intervention: Active Arm N-acetyl Cysteine (NAC), Placebo Arm
March 27, 2019
215
NCT02864654
Unknown status
Unknown status
Effectiveness and Safety of Adipose-Derived Regenerative Cells for the Treatment of Critical Lower Limb Ischemia
Conditions: Critical Limb Ischemia; Arteriosclerosis Obliterans; Peripheral Arterial Disease; Thromboangiitis Obliterans; Diabetic Angiopathies
Intervention: ADRC Injection, ADRC Isolation, Liposuction
Conditions: Critical Limb Ischemia; Arteriosclerosis Obliterans; Peripheral Arterial Disease; Thromboangiitis Obliterans; Diabetic Angiopathies
Intervention: ADRC Injection, ADRC Isolation, Liposuction
August 11, 2016
216
NCT04058626
Recruiting
Recruiting
TEsting for Arterial Disease in Diabetes (TrEAD) Study
Conditions: Diabetic Foot; Peripheral Arterial Disease; Diabetic Foot Ulcer; Peripheral Vascular Diseases; Peripheral Artery Disease; Critical Limb Ischemia; Critical Lower Limb Ischemia
Intervention: Transcutaneous Pressure Of Oxygen (TcPO2), Toe Brachial Pressure Index (TBPI), Podiatry Ankle Duplex Scan (PAD-scan), Duplex Assist, Ankle Brachial Pressure Index (ABPI)
Conditions: Diabetic Foot; Peripheral Arterial Disease; Diabetic Foot Ulcer; Peripheral Vascular Diseases; Peripheral Artery Disease; Critical Limb Ischemia; Critical Lower Limb Ischemia
Intervention: Transcutaneous Pressure Of Oxygen (TcPO2), Toe Brachial Pressure Index (TBPI), Podiatry Ankle Duplex Scan (PAD-scan), Duplex Assist, Ankle Brachial Pressure Index (ABPI)
August 14, 2019
217
NCT04027244
Recruiting
Recruiting
Leg Ischaemia Management Collaboration
Conditions: Peripheral Arterial Disease; Critical Limb Ischemia; Frailty; Cognitive Impairment; Coronary Artery Disease
Conditions: Peripheral Arterial Disease; Critical Limb Ischemia; Frailty; Cognitive Impairment; Coronary Artery Disease
July 18, 2019
218
NCT01942941
Completed
Completed
Peripheral Vascular Disease and Nerve Stimulation
Conditions: Critical Limb Ischaemia; Claudication; Ulcers; Varicose Veins; Post Angioplasty
Intervention: Geko™ Electrical Stimulation
Conditions: Critical Limb Ischaemia; Claudication; Ulcers; Varicose Veins; Post Angioplasty
Intervention: Geko™ Electrical Stimulation
July 22, 2019
219
NCT03448029
Recruiting
Recruiting
RECCORD (Recording Courses of Vascular Diseases) Registry
Conditions: Vascular Diseases; Peripheral Artery Disease; Claudication; Critical Limb Ischemia; Diabetic Foot
Conditions: Vascular Diseases; Peripheral Artery Disease; Claudication; Critical Limb Ischemia; Diabetic Foot
January 22, 2019
220
NCT02395744
Completed
Completed
The COPPER-B Trial
Conditions: Cardiovascular Diseases; Peripheral Vascular Disease; Arterial Occlusive Diseases; Peripheral Arterial Disease; Critical Limb Ischemia
Intervention: Paclitaxel Administration Using The OPC
Conditions: Cardiovascular Diseases; Peripheral Vascular Disease; Arterial Occlusive Diseases; Peripheral Arterial Disease; Critical Limb Ischemia
Intervention: Paclitaxel Administration Using The OPC
February 24, 2017
221
NCT03594344
Recruiting
Recruiting
Additional Hyperbaric Oxygen After Lower Extremity Amputation
Conditions: Diabetes Mellitus; Claudication, Intermittent; Critical Limb Ischemia; Osteomyelitis; Amputation; Lower Extremity Ulcer; Diabetic Angiopathy; Diabetic Neuropathies; Diabetic Foot
Intervention: Hyperbaric Oxygen Therapy
Conditions: Diabetes Mellitus; Claudication, Intermittent; Critical Limb Ischemia; Osteomyelitis; Amputation; Lower Extremity Ulcer; Diabetic Angiopathy; Diabetic Neuropathies; Diabetic Foot
Intervention: Hyperbaric Oxygen Therapy
January 18, 2019
222
NCT00282646
Completed
Completed
Safety and Feasibility Study of Autologous Bone Marrow Cell Transplantation in Patients With Peripheral Arterial Occlusive Disease (PAOD)
Conditions: Arterial Occlusive Diseases
Intervention: Intraarterial Stem Cell Therapy, Stem Cells
Conditions: Arterial Occlusive Diseases
Intervention: Intraarterial Stem Cell Therapy, Stem Cells
August 23, 2011
223
NCT00539266
Unknown status
Unknown status
Autologous Bone Marrow-derived Mononuclear Cells for Therapeutic Arteriogenesis in Patients With Limb Ischemia
Conditions: Intermittent Claudication; Peripheral Vascular Diseases
Intervention: Bone Marrow Derived Mononuclear Cells, Placebo
Conditions: Intermittent Claudication; Peripheral Vascular Diseases
Intervention: Bone Marrow Derived Mononuclear Cells, Placebo
July 5, 2011
224
NCT00300040
Terminated
Terminated
Safety/Feasibility Study of HBOC-201 in Amputation at/Below Knee From Critical Lower Limb Ischemia
Conditions: Peripheral Vascular Disease
Intervention: Hemoglobin Glutamer 250 - Bovine, 6% Hydroxyethylstarch
Conditions: Peripheral Vascular Disease
Intervention: Hemoglobin Glutamer 250 - Bovine, 6% Hydroxyethylstarch
May 15, 2008
225
NCT01630070
Completed
Completed
Single Arm Study With a Nitinol Self-Expanding Paclitaxel-Eluting Stent to Treat BTK Arteries
Conditions: Peripheral Arterial Disease
Intervention: Self-expandable Drug Eluting Stent
Conditions: Peripheral Arterial Disease
Intervention: Self-expandable Drug Eluting Stent
March 6, 2015
226
NCT01147419
Unknown status
Unknown status
Comparison of Stent and Prothesis Bypass in Superficial Femoral Artery
Conditions: Arterial Occlusive Diseases; Vascular Diseases
Intervention: Stent, Femoral-popliteal Bypass With Artificial Blood Vessel
Conditions: Arterial Occlusive Diseases; Vascular Diseases
Intervention: Stent, Femoral-popliteal Bypass With Artificial Blood Vessel
July 6, 2010
227
NCT02096757
Completed
Completed
The Use of Fish Oil to Reduce Inflammation Caused by a Peripheral Vascular Intervention
Conditions: Peripheral Arterial Disease
Intervention: Pro-Omega, Pro-Omega Placebo
Conditions: Peripheral Arterial Disease
Intervention: Pro-Omega, Pro-Omega Placebo
January 2, 2018
228
NCT03149913
Recruiting
Recruiting
Local Paclitaxel or Balloon Angioplasty Below the Knee
Conditions: Stenosis; Occlusion; Restenosis
Intervention: SequentPlease OTW Paclitaxel Coated Balloon Catheter, Conventional Uncoated Balloon For BTK Endovascular Therapy
Conditions: Stenosis; Occlusion; Restenosis
Intervention: SequentPlease OTW Paclitaxel Coated Balloon Catheter, Conventional Uncoated Balloon For BTK Endovascular Therapy
May 10, 2017
229
NCT02371785
Completed
Completed
Robotic-Assisted Peripheral Intervention for Peripheral Arterial Disease
Conditions: Peripheral Arterial Disease
Intervention: CorPath 200 System
Conditions: Peripheral Arterial Disease
Intervention: CorPath 200 System
March 18, 2019
230
NCT00145262
Unknown status
Unknown status
TACT-NAGOYA: Therapeutic Angiogenesis Using Cell Transplantation
Conditions: Buerger Disease; Arteriosclerosis Obliterans
Intervention: Autologous Bone Marrow Mononuclear Cell Implantation
Conditions: Buerger Disease; Arteriosclerosis Obliterans
Intervention: Autologous Bone Marrow Mononuclear Cell Implantation
December 29, 2005
231
NCT02942966
Active, not recruiting
Active, not recruiting
Tack Optimized Balloon Angioplasty Study of the Tack Endovascular System® in Below the Knee Arteries
Conditions: Peripheral Arterial Disease
Intervention: Tack Endovascular System
Conditions: Peripheral Arterial Disease
Intervention: Tack Endovascular System
May 2, 2019
232
NCT00059644
Terminated
Terminated
Efficacy/Safety of Ecraprost in Lipid Emulsion for Treatment of Critical Leg Ischemia Due to Peripheral Arterial Disease
Conditions: Peripheral Vascular Disease
Intervention: Ecraprost In Lipid Emulsion
Conditions: Peripheral Vascular Disease
Intervention: Ecraprost In Lipid Emulsion
June 23, 2005
233
NCT01861327
Unknown status
Unknown status
The Use of Carbon Dioxide as a Contrast Media for Performing Endovascular Procedures
Conditions: Critical Lower Limb Ischemia; Abdominal Aortic Aneurysms
Intervention: CO2, Iodine Contrast Media
Conditions: Critical Lower Limb Ischemia; Abdominal Aortic Aneurysms
Intervention: CO2, Iodine Contrast Media
February 23, 2017
234
NCT03042572
Not yet recruiting
Not yet recruiting
Allogeneic Mesenchymal Stromal Cells for Angiogenesis and Neovascularization in No-option Ischemic Limbs
Conditions: Peripheral Arterial Disease; Cardiovascular Diseases; Vascular Diseases
Intervention: Allogeneic Mesenchymal Stromal Cell, Placebo
Conditions: Peripheral Arterial Disease; Cardiovascular Diseases; Vascular Diseases
Intervention: Allogeneic Mesenchymal Stromal Cell, Placebo
May 2, 2018
235
NCT02956993
Completed
Completed
Safety/Feasibility of Vonapanitase Following Angioplasty for Patients With Peripheral Artery Disease (PAD) Below the Knee (BTK)
Conditions: Peripheral Artery Disease
Intervention: Vonapanitase, Placebo
Conditions: Peripheral Artery Disease
Intervention: Vonapanitase, Placebo
April 30, 2019
236
NCT00516308
Terminated
Terminated
A Non-Randomized Study of the NightHawk Peripheral Plaque Excision System During Plaque Excision of Peripheral Arterial Disease
Conditions: Peripheral Vascular Diseases
Intervention: NightHawk
Conditions: Peripheral Vascular Diseases
Intervention: NightHawk
January 16, 2008
237
NCT00059657
Completed
Completed
Efficacy/Safety of Ecraprost in Lipid Emulsion for Treatment of Critical Leg Ischemia Due to Peripheral Arterial Disease
Conditions: Peripheral Vascular Disease
Intervention: Ecraprost In Lipid Emulsion
Conditions: Peripheral Vascular Disease
Intervention: Ecraprost In Lipid Emulsion
May 17, 2006
238
NCT00041925
Completed
Completed
Prevention of Autogenous Vein Graft Failure in Peripheral Artery Bypass Procedures
Conditions: Peripheral Vascular Diseases; Arterial Occlusive Diseases; Ischemia; Graft Occlusion, Vascular; Hyperplasia
Intervention: CGT003 (E2F Duplex Decoy)
Conditions: Peripheral Vascular Diseases; Arterial Occlusive Diseases; Ischemia; Graft Occlusion, Vascular; Hyperplasia
Intervention: CGT003 (E2F Duplex Decoy)
July 14, 2005
239
NCT01450722
Unknown status
Unknown status
Paclitaxel Eluting Stent in Long SFA Obstruction: A Prospective, Randomized Comparison With Bypass Surgery
Conditions: Chronic Lower Limb Ischemia; Peripheral Athero Obstructive Disease; Critical Ischemia; Claudication
Intervention: Bypass Surgery, Stent Placement, Stent Placement
Conditions: Chronic Lower Limb Ischemia; Peripheral Athero Obstructive Disease; Critical Ischemia; Claudication
Intervention: Bypass Surgery, Stent Placement, Stent Placement
March 15, 2018
240
NCT02097186
Unknown status
Unknown status
Preconditioning Shields Against Vascular Events in Surgery
Conditions: Abdominal Aortic Aneurysm; Carotid Atherosclerosis; Critical Lower Limb Ischaemia
Intervention: Remote Ischaemic Preconditioning
Conditions: Abdominal Aortic Aneurysm; Carotid Atherosclerosis; Critical Lower Limb Ischaemia
Intervention: Remote Ischaemic Preconditioning
December 11, 2014
241
NCT01691911
Completed
Completed
Preconditioning Shields Against Vascular Events in Surgery
Conditions: Abdominal Aortic Aneurysm; Carotid Atherosclerosis; Critical Lower Limb Ischaemia
Intervention: Remote Preconditioning
Conditions: Abdominal Aortic Aneurysm; Carotid Atherosclerosis; Critical Lower Limb Ischaemia
Intervention: Remote Preconditioning
June 2, 2015
242
NCT01824069
Completed
Completed
Treatment CLI Nonrevascularizable Lower Limb With Cell Therapy
Conditions: Nonrevascularizable Critical Ischemia of the Lower Limbs
Intervention: Intramuscular Injection Of A Suspension Of Adult Mesenchymal Stem Cells Derived
Conditions: Nonrevascularizable Critical Ischemia of the Lower Limbs
Intervention: Intramuscular Injection Of A Suspension Of Adult Mesenchymal Stem Cells Derived
June 14, 2016
Last Updated
The last updated date is the most recent date when changes to a clinical trial were
submitted to ClinicalTrials.gov. There is often a delay of a few days before the
updated trial is available on the clinical trials website.
Specify a From date to find the most recently changed trials. Specify both From and To dates to find trials changed during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
Specify a From date to find the most recently changed trials. Specify both From and To dates to find trials changed during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
First Received
The first received date is the date when the clinical trial was first submitted
to ClinicalTrials.gov. There is often a delay of a few days before the
trial is available on the clinical trials website.
Clinical trial records are often updated after they have been published. The first received, last updated, start, and end dates are all displayed in the full text view of the clinical trial.
Specify a From date to find the most recent trials. Specify both From and To dates to find trials submitted during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
Clinical trial records are often updated after they have been published. The first received, last updated, start, and end dates are all displayed in the full text view of the clinical trial.
Specify a From date to find the most recent trials. Specify both From and To dates to find trials submitted during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
Safety Issue
If selected, restricts search results to those studies which have
an outcome measure designated as a safety issue. Note that this is a
poor estimate of the safety of a treatment or intervention, but it is
all we have now.
Funded By
Studies are supported by one or more organizations called sponsors.
Support includes contributions of facilities, expertise, and/or financial resources.
All sponsors in the database have been assigned one of the following organization types:
National Institutes of Health (NIH)
Other U.S. Federal Agency - Food and Drug Administration (FDA), Centers for Disease Control and Prevention (CDC), Department of Veterans Affairs (VA), etc.
Industry - the pharmaceutical companies
University/Organization - all others, including community-based organizations
Click the check box to the left of each organization type that you wish to include in your search. You can select more than one organization type. If you do not select any type, all types will be included.
National Institutes of Health (NIH)
Other U.S. Federal Agency - Food and Drug Administration (FDA), Centers for Disease Control and Prevention (CDC), Department of Veterans Affairs (VA), etc.
Industry - the pharmaceutical companies
University/Organization - all others, including community-based organizations
Click the check box to the left of each organization type that you wish to include in your search. You can select more than one organization type. If you do not select any type, all types will be included.
Study Phase
Click the check box to the left of each study phase that you wish to include in your search. You can select more than one study phase. If you do not select a any phase, all phases will be included.
Most clinical trials are designated as phase 1, 2, 3, or 4, based on the type of questions
that study is seeking to answer:
In Phase 1 (Phase I) clinical trials, researchers test a new drug or treatment in a small group of people (20-80) for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
In Phase 2 (Phase II) clinical trials, the study drug or treatment is given to a larger group of people (100-300) to see if it is effective and to further evaluate its safety.
In Phase 3 (Phase III) clinical trials, the study drug or treatment is given to large groups of people (1,000-3,000) to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
In Phase 4 (Phase IV) clinical trials, post marketing studies delineate additional information including the drug's risks, benefits, and optimal use.
These phases are defined by the Food and Drug Administration in the Code of Federal Regulations.
In Phase 1 (Phase I) clinical trials, researchers test a new drug or treatment in a small group of people (20-80) for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
In Phase 2 (Phase II) clinical trials, the study drug or treatment is given to a larger group of people (100-300) to see if it is effective and to further evaluate its safety.
In Phase 3 (Phase III) clinical trials, the study drug or treatment is given to large groups of people (1,000-3,000) to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
In Phase 4 (Phase IV) clinical trials, post marketing studies delineate additional information including the drug's risks, benefits, and optimal use.
These phases are defined by the Food and Drug Administration in the Code of Federal Regulations.
Click the check box to the left of each study phase that you wish to include in your search. You can select more than one study phase. If you do not select a any phase, all phases will be included.
Age Group
Studies may be designed for participants of particular ages:
Children (birth-17 yrs old)
Adults (18-65 yrs old)
Senior (66+ yrs old)
Click the check box to the left of each age group that you wish to include in your search. You can select more than one age group. If you do not select a any group, all groups will be included.
Children (birth-17 yrs old)
Adults (18-65 yrs old)
Senior (66+ yrs old)
Click the check box to the left of each age group that you wish to include in your search. You can select more than one age group. If you do not select a any group, all groups will be included.
Gender
Searches can be restricted to studies which accept female or male participants.
Location Terms
If you are interested in a specific city (such as Los Angeles) or facility
name (such as the Mayo Clinic), enter it as a location term. Not all studies
include this level of detail, but if they do, this will find them.
Countries and States
Trials are often conducted at many locations around the world.
Select up to three locations to find trials conducted in
specific countries. Some countries (currently limited to the
United States, Canada, and Australia), locations can be narrowed
further by selecting a state.
Study IDs
Each trial is assigned one or more identification numbers by the institute, agency,
or organization sponsoring the trial. In addition, clinical trials assigns a
unique NCT identifier of the form NCTxxxxxxxx where each x is a numeric digit.
Use this box to search for a trial by NCT identifier or any other study
identification numbers.
Examples:
Examples:
NCT00001789
97-h-0197
ia0006
actg 076
97-h-0197
ia0006
actg 076
Sponsor (Lead)
Use this box to specify the name of an institute, organization, or company that is
conducting a trial.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
A search in this area will check only the sponsor field. To also look for collaborators, use the Sponsor/Collaborators search box.
When the Exact Match checkbox is checked, the sponsor name in the study must exactly match the sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
A search in this area will check only the sponsor field. To also look for collaborators, use the Sponsor/Collaborators search box.
When the Exact Match checkbox is checked, the sponsor name in the study must exactly match the sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
Sponsor/Collaborators
Use this box to specify institutes, organizations, or companies that are
conducting or otherwise supporting a trial.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
Searching this area will look in both the sponsor field and in the collaborators field. To only look in the sponsor field, use the Sponsor (Lead) search box.
When the Exact Match checkbox is checked, the name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
Searching this area will look in both the sponsor field and in the collaborators field. To only look in the sponsor field, use the Sponsor (Lead) search box.
When the Exact Match checkbox is checked, the name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
Outcome Measures
Use this box to specify an outcome measure used to evaluate trial results.
Examples:
weight loss
heart failure
suicide
Outcome measures are used to evaluate trial results. For example, an obesity treatment
might be evaluated by a measure of weight loss after 6 months. Measures can also be used
to quantify side effects, such as number of myocardial infarctions,
number of patients with heart arrhythmia, number of suicides, etc.
Use this box to specify an outcome measure used to evaluate trial results.
Examples:
weight loss
heart failure
suicide
Interventions
Use this box to specify drugs, devices, procedures, or vaccines used in a trial.
Examples:
clofibrate
cyclosporine
vitamin e
Interventions refer to the drug, vaccine, procedure, device, or other potential treatment being studied.
Interventions can also include less intrusive possibilities such as surveys, education, and interviews.
Use this box to specify drugs, devices, procedures, or vaccines used in a trial.
Examples:
clofibrate
cyclosporine
vitamin e
Conditions
Use this box to specify the conditions being studied.
Examples:
lupus
heart attack
leukemia
risk factors for breast cancer
Conditions usually refer to a disease, disorder, syndrome, illness, or injury. In ClinicalTrials.gov,
conditions include any health issue worth studying, such as lifespan, quality of life, health risks, etc.
Use this box to specify the conditions being studied.
Examples:
lupus
heart attack
leukemia
risk factors for breast cancer
Study Type
There are three types of studies available in ClinicalTrials.gov:
There are three types of studies available in ClinicalTrials.gov:
Interventional:
Observational:
Expanded Access:
Studies where individuals are assigned to receive specific interventions.
Participants may receive diagnostic, therapeutic or other types of interventions.
Assignment of the intervention may or may not be random.
Individuals are tracked and biomedical and/or health outcomes are assessed.
Observational:
Studies without an intervention.
Studies where biomedical and/or health outcomes are assessed in a pre-defined group of individuals.
Participants may receive diagnostic, therapeutic, or other interventions, but the investigator
does not assign specific interventions to the participants of the study.
Expanded Access:
Records describing the procedure for obtaining an experimental drug or device for patients who
are failing on currently available treatments for their condition and also are unable to
participate in ongoing clinical trials. Expanded Access records are used to register all
types of non-protocol access to experimental treatments, including protocol exception,
single-patient IND, treatment IND, compassionate use, emergency use, continued access and parallel track.
Study Results
Searches can be restricted to studies with or without results.
The inclusion of study results is a relatively new feature of ClinicalTrials.gov. Collection of results began in September of 2008. Almost all older studies and some newer studies do not include results. As time goes on, there will be more results available.
The inclusion of study results is a relatively new feature of ClinicalTrials.gov. Collection of results began in September of 2008. Almost all older studies and some newer studies do not include results. As time goes on, there will be more results available.
Recruitment Status
Also known as Enrollment Status.
Not all clinical trials in this database are accepting new participants. If you are looking for studies that are currently recruiting participants, will be recruiting in the future, or are about drugs that are available for expanded access, select Open Studies in the recruitment menu.
If you are interested in all trials, whether they are recruiting new participants or not, leave the menu with All Studies selected.
Trials may not be recruiting because they are full, completed, or halted for various reasons. In addition, some trials have very restrictive eligibility requirements and must seek participants by invitation only. To see these studies, Select Closed Studies in the recruitment menu.
Full list of all possible recruitment status values:
Open recruitment status values:
Closed recruitment status values:
Values are color coded (as shown) in the search results.
Not all clinical trials in this database are accepting new participants. If you are looking for studies that are currently recruiting participants, will be recruiting in the future, or are about drugs that are available for expanded access, select Open Studies in the recruitment menu.
If you are interested in all trials, whether they are recruiting new participants or not, leave the menu with All Studies selected.
Trials may not be recruiting because they are full, completed, or halted for various reasons. In addition, some trials have very restrictive eligibility requirements and must seek participants by invitation only. To see these studies, Select Closed Studies in the recruitment menu.
Full list of all possible recruitment status values:
Open recruitment status values:
Recruiting,
Not yet recruiting, or
Available for expanded access.
Not yet recruiting, or
Available for expanded access.
Closed recruitment status values:
Active, not recruiting,
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Search Terms
Use this box to specify general search terms found anywhere in the trial record.
Multiple terms can be separated by an AND (all uppercase).
Examples:
type ii diabetes
veterans affairs medical center
heart attacks in older adults
nhlbi AND heart disease
Cisplatin AND safety study
Multiple terms can be separated by an AND (all uppercase).
Examples:
type ii diabetes
veterans affairs medical center
heart attacks in older adults
nhlbi AND heart disease
Cisplatin AND safety study
Help for Searching clinical trials
Help Topics:
Basic Search:
On the Basic Search page, enter a word or word(s) that you want to use to find studies.
These may include diseases, interventions, and/or locations.
Medical terms are often several words long, such as Percutaneous Coronary Intervention. To only find studies where the words are together as a phrase, put the term in quotes (e.g., "Percutaneous Coronary Intervention"). If you search for a multi-word term without quotes, studies with all words together as a phrase will appear higher in the results list than studies where the words are separated and spread throughout the document. For example, a search for Heart Attack will list a study about,
A search for "Heart Attack" would not find the second study. Synonyms are known for some terms and are used where possible. For example, a search for Heart Attack will also find occurrences of Myocardial Infarction.
Medical terms are often several words long, such as Percutaneous Coronary Intervention. To only find studies where the words are together as a phrase, put the term in quotes (e.g., "Percutaneous Coronary Intervention"). If you search for a multi-word term without quotes, studies with all words together as a phrase will appear higher in the results list than studies where the words are separated and spread throughout the document. For example, a search for Heart Attack will list a study about,
Use of a Pacemaker Following a Heart Attack.
higher than the study,
Heart Defects and Transient Ischemic Attacks
A search for "Heart Attack" would not find the second study. Synonyms are known for some terms and are used where possible. For example, a search for Heart Attack will also find occurrences of Myocardial Infarction.
Advanced Search:
Many searches are a single term and can be performed with a few words in the
search box. But, sometimes you need more control. Click on the Advanced Search tab
(if starting a new search) or Refine Search tab (if modifying an existing search)
to show additional search fields.
The additional search fields can be used to limit your search results. Note that it is not necessary to fill in all the fields, only those that are needed for your search. If you are finding too few studies, consider clearing a field and searching again.
Search Terms:
Recruitment:
Interventions:
Outcomes Measures:
Sponsor/Collaborators:
Sponsor (Lead):
Study IDs:
Country/State:
Location Terms:
Gender:
Age Group:
Phase:
Funded By:
Safety Issue:
First Received:
Last Updated:
The additional search fields can be used to limit your search results. Note that it is not necessary to fill in all the fields, only those that are needed for your search. If you are finding too few studies, consider clearing a field and searching again.
Search Terms:
Performs a general search in all sections of the study record, including title,
description, conditions, interventions, locations, etc. Terms in this field are
searched the same as Basic Search.
Recruitment:
Limits search results to studies that are open or closed. New volunteers may be
able to participate in open studies, but not closed studies.
Open recruitment status values:
Closed recruitment status values:
Values are color coded (as shown) in the search results.
Study Results:Open recruitment status values:
Recruiting,
Not yet recruiting, or
Available for expanded access.
Not yet recruiting, or
Available for expanded access.
Closed recruitment status values:
Active, not recruiting,
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Values are color coded (as shown) in the search results.
Limits search results based on whether the study has results or not:
Study Type:
All Studies,
Studies With Results, or
Studies Without Results
The inclusion of Study Results is a new feature of ClinicalTrials.gov.
Only a few studies have results available.Studies With Results, or
Studies Without Results
Limits search results to any of the following study types:
Conditions:
Interventional,
Observational, or
Expanded Access
Observational, or
Expanded Access
Performs a search on fields describing the diseases or conditions being studied.
Interventions:
Performs a search on fields listing the drugs or interventions being studied.
Outcomes Measures:
Performs a search on fields listing the outcome measures used to quantify study results.
Sponsor/Collaborators:
Performs a search on fields listing the sponsor and collaborators of a study.
When the Exact Match checkbox is checked, the sponsor/collaborator name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck in the sponsor/collaborator field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
When the Exact Match checkbox is checked, the sponsor/collaborator name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck in the sponsor/collaborator field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Sponsor (Lead):
Performs a search on the sponsor field of a study.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the "sponsor" is decided by the data provider.
When the Exact Match checkbox is checked, the lead sponsor name in the study must exactly match the lead sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the "sponsor" is decided by the data provider.
When the Exact Match checkbox is checked, the lead sponsor name in the study must exactly match the lead sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Study IDs:
Performs a search on fields listing ID numbers.
Country/State:
Trials are often conducted at many locations around the world.
Select up to three locations to find trials conducted in
specific countries. Some countries (currently limited to the
United States, Canada, and Australia), locations can be narrowed
further by selecting a state (e.g., United States, Alabama).
Location Terms:
Finds studies in specific locations such as a city (Los Angeles) or facility (Mayo Clinic).
Not all studies include this level of detail, but if they do, this will find them.
Gender:
Limits search results to those studies that accept female or male participants.
Age Group:
Limits search results to those studies that include at least one of the specified age
ranges. More than one age group can be selected.
Phase:
Limits search results to studies that are labeled with at least one of the specified
phases. More than one Phase can be selected.
Funded By:
Limits search results to studies that have at least one sponsor of the specified types.
More than one sponsor type can be selected.
Safety Issue:
Limits search results to studies that have at least one outcome measure designated as a safety issue.
First Received:
Limits search results to studies that were received by clinical trials within a
specified date range. The "From" or "To" field can be left blank.
Last Updated:
Limits search results to studies that were modified within a
specified date range. The "From" or "To" field can be left blank.
Refine Search:
Searches display a list of studies found (List Results tab). If you are not content with
the search results, click on the Refine Search tab at the top of the list to modify your
search.
Add terms to empty fields to search within your current result. You can also add terms to fields that contain terms. For best results, use an AND (all upper case) as a separator between terms in the same field.
For example:
When you are done making changes, click Search to display the new results.
Add terms to empty fields to search within your current result. You can also add terms to fields that contain terms. For best results, use an AND (all upper case) as a separator between terms in the same field.
For example:
heart attack
heart attack AND aspirin
heart attack AND aspirin AND older adults
heart attack AND aspirin AND older adults AND California
heart attack AND aspirin
heart attack AND aspirin AND older adults
heart attack AND aspirin AND older adults AND California
When you are done making changes, click Search to display the new results.
Search Expressions:
Use AND (all upper case) to find study records that contain all terms connected by AND.
For example:
Use OR (all upper case) to find study records that contain either term connected by OR.
For example:
Use NOT (all upper case) to find study records that do not contain the term following NOT.
For example:
Likewise, AND, OR, NOT, and parentheses can be used to create more complicated search expressions.
For example:
Note that the use of AND and OR as logical operators can be confusing.
An appropriate search for a list such as,
To search for AND as a word, instead of using it as an operator, put it in quotes.
Likewise, you can quote OR, NOT, and parentheses.
For example:
prostate cancer AND radiation
heart disease AND stroke AND California
heart disease AND stroke AND California
Use OR (all upper case) to find study records that contain either term connected by OR.
For example:
Aspirin OR ibuprofen
heart disease OR heart attack
heart disease OR heart attack
Use NOT (all upper case) to find study records that do not contain the term following NOT.
For example:
Immunodeficiency NOT AIDS
Likewise, AND, OR, NOT, and parentheses can be used to create more complicated search expressions.
For example:
prostate cancer AND NOT ( radiation OR homeopathic remedies )
( heart disease OR heart attack ) AND ( stroke OR clot )
( heart disease OR heart attack ) AND ( stroke OR clot )
Note that the use of AND and OR as logical operators can be confusing.
An appropriate search for a list such as,
Ear, Nose, and Throat Conditions
is the expression
( Ear OR Nose OR Throat ) AND Conditions
Fortunately, search will do a pretty good job of finding the right studies either way.To search for AND as a word, instead of using it as an operator, put it in quotes.
Likewise, you can quote OR, NOT, and parentheses.